The contemporary principles of pharmacotherapy in atopic dermatitis to children

Abstract

Introduction. In the Republic of Moldova atopic dermatitis to children is increasing as in other countries and the prevalence of this disease has increased from 11.9% in 2006, to 19.6% children, in 2016. Aim of the study. Elucidation of the contemporary aspects of etiological, clinical and pharmacotherapeutic features of atopic dermatitis to children. Materials and methods. The analysis of 97 cases of atopic dermatitis to children for 2 years, which were addressed to family doctors at the polyclinics. Results. Of the study group with atopic dermatitis, it was established that 42.5% belonged to the extrinsic subtype of atopic dermatitis to children, and 57.5% of the patients belonged to the intrinsic subtype. To 3% of children is the mild form of evolution, in 35% of cases the evolution is average and in 52% serious cases. Of the group of children which were included in study, 11 have other associated allergic diseases (27%), respectively 8 with allergic rhinitis (20%) and 3 with bronchial asthma (7.5%). Glucocorticosteroids are first-line remedies in topical treatment of atopic dermatitis, such as mometasone, clobetasol and fluticasone creams. Of the first generation of antihistamines,such as clemastine, chloropiramine and ciproheptadine are prescribed with preselection in acute forms of the disease. In subacute and chronic forms, second-and thirdgeneration antihistamines are generally used.Conclusions. Glucocorticosteroids are indicated for children with moderate, severe or recurrent forms of atopic dermatitis to children. Generations of antihistamines of the first generation are prescribed with predelection in acute forms, while second- and third-generation antihistamines are used in subacute and chronic forms.