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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/11267
Title: Experimental myocadial infarction and Interleukine-6 modifications
Authors: Timercan, Tatiana
Keywords: myocardial injury;cytokine;IL-6
Issue Date: 2018
Publisher: MedEspera
Citation: TIMERCAN, Tatiana. Experimental myocadial infarction and Interleukine-6 modifications. In: MedEspera: the 7th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2018, p. 200.
Abstract: Introduction. The inflammatory response, manifested as acute necrosis, is induced by ischemia in infracted myocardium. Myocardial remodelling is one of the complications, which leads to arrhythmias and heart failure. Interleukine-6 (IL-6) is a cytokine involved in tissue remodelling, as well as in the pro- and anti-inflammatory response pathways. Post infarct it promotes myocyte hypertrophy and myocardial dysfunction. In addition, IL-6 inhibits cardiomyocyte apoptosis. Aim of the study. To evaluate serum and homogenate IL-6 level in isoproterenol-induced acute myocardial infarction. Materials and methods. Forty adult male rats (Ratta albicans) were divided into five groups: L1 – intact (n=11); L2 – control animals which were administrated NaCl 0.9% (n=11); L3 (n=6), L4 (n=6) and L5 (n=6) included the animals with experimental myocardial infarction, reproduced by injecting subcutaneously isoproterenol hydrochloride 100 mg/kg (one dose). Rats were anesthetized, and sacrificed at 6h, 24h and 7 days respectively. For IL-6 assessment, we use standard Rat IL-6 ELISA kit (Beijing 4A Biotech Co. Ltd). The results were analyzed by Kruskal-Wallis nonparametric test using SPSS version 23. Discussion Results. The investigated groups have not presented any statistically significant difference neither in homogenate IL-6 content (p = 0.098), no in serum IL-6 level (p = 0,322). At the same time, higher amounts of both homogenate and serum IL-6 were registered in experimental groups compared to intact and control groups. Conclusions. Inflammation plays a significant role in the pathogenesis of myocardial ischemic injury. Infarcted myocardium increases the production of IL-6. Increased IL-6 levels for a prolonged time can indicate associated inflammation and elevated risk of second myocardial infarction. Serum IL-6 level following AMI can be used for the inflammatory process monitoring. In order to prove it the research should be enlarged, and statistical correlations will be performed.
URI: https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf
http://repository.usmf.md/handle/20.500.12710/11267
Appears in Collections:MedEspera 2018

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