- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- MedEspera: International Medical Congress for Students and Young Doctors
- MedEspera 2020
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/11744
Title: | Ischemia-reperfusion injury in ovaries |
Authors: | Bulat, Ana-Maria |
Keywords: | ovarian torsion;ischemia-reperfusion injury;ROS |
Issue Date: | 2020 |
Publisher: | MedEspera |
Citation: | BULAT, Ana-Maria. Ischemia-reperfusion injury in ovaries. In: MedEspera: the 8th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2020, p. 269-270 |
Abstract: | Introduction. Ovarian torsion is a condition in which the ovary twists around its pedicle
resulting in diminished blood flow with the ischemia of the organ. It is the fifth most common
cause of acute abdomen in women and requires detorsion to treat. Following reperfusion a
cascade of reactions is initiated with the formation of reactive oxygen and nitrogen species
(ROS, RNS), which lead to cell injury. Aim of the study. To determine the effects of ischemia-reperfusion injury on ovarian viability
and later fertility in patients with ovarian torsion.
Materials and methods. Studies from the specialized journals of PubMed, Medline, Hinari
were used, which focused on the structural and functional changes in detorsioned ovaries, their
viability, follicular reserve and fertility.
Results. Ischemia in torsioned ovaries leads to the formation of ROS and RNS such as
superoxide anion radicals, nitric oxide and others. Following reperfusion the influx of large
amounts of oxygen leads to the increase of ROS production which causes inflammation and
tissue damage. Therefore the damage to the tissue is exponentially more severe in the
reperfusion rather than in the ischemic phase. ROS are responsible for the peroxidation of the
membrane lipids with the formation of malonic dialdehyde (MDA), increased cell membrane
permeability, DNA chain breaks and mutations, massive influx of Ca2+ from its binding sites
with the release of cytochrome c from the mitochondria and activation of caspase-dependent
cell death. These free radicals are scavenged by the antioxidant enzymes, such as superoxide
dismutase, catalase and by vitamin C, which seems to be present in high concentrations in the
ovary and can help partly minimize the cell damage. Studies in patients with ovarian torsion
show that the majority of detorsions are successful even in later stages with the recovery of
normal blood flow and the preservation of the organ structure. Follicular reserve has also been
shown to be maintained even after prolonged periods of ischemia. Few studies are available
for the fertility of these patients, but nonetheless they show pregnancies in the majority of cases.
Conclusions. The ovary seems to possess a certain degree of resistance to ischemia-reperfusion
injury even after long periods of ischemia as shown by the preservation of its structure,
follicular reserves and fertility, but further studies are required to assess all of the consequences. Thus, conservative treatment of ovarian torsion is encouraged with gradual
detorsion of the organ. |
URI: | http://repository.usmf.md/handle/20.500.12710/11744 medespera.asr.md/wp-content/uploads/ABSTRACT-BOOK.pdf |
Appears in Collections: | MedEspera 2020
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