Synergies between ozone therapy and epigenetic factors

Abstract

Introduction. We have known for decades the functions that ozone, normally produced by our immune system, performs on our body: anti-inflammatory, pain-relieving, antispasmodic, anti-bacterial, anti-viral action, improves the functionality of the microcirculation and mitochondria, increases the production of ATP and Nitric Oxide. All this, if we use concentrations lower than 70/80 pg/ml, without genotoxic or cytotoxic effects. Objective. To evaluate the effects of ozone therapy at various concentrations on inflammatory cytokines and to understand the synergy between ozone therapy and epigenetic factors in reducing the inflammatory component in serious inflammatory pathologies. Materials and Methods. We observed that with autohemoinfusions at a concentration of 20 pg/ml, the inflammatory cytokines TNF-a and IL-6 begin to decrease. IL-8 and IL-17 begin to decline with at least 30 pg/ml, but we obtain their maximum reduction at a concentration of 50 pg/ml. We know that at concentrations above 70-80 pg/ml, cytotoxic effects begin. We administered large autohemoinfusions of 13,000- 14,000 у ozone to achieve the greatest anti-inflammatory effects in serious inflammatory pathologies, while being cautious about the potential for excessive reduction of the inflammatory response with higher quantities. Results. At a concentration of 20 pg/ml, TNF-a and IL-6 levels begin to decrease. IL-8 and IL-17 levels decline with at least 30 pg/ml and reach maximum reduction at 50 pg/ml. The most significant anti-inflammatory effects were observed with large autohemoinfusions of 13,000-14,000 у ozone. Conclusions. Epigenetics studies how age, environmental factors, diet, posture, stress, emotions, and physical activity can modify or silence gene expression of mutations, even in homozygous twins. Scientific publications increasingly correlate the clinical severity of various pathologies with the synergy of various epigenetic factors. We are convinced that the synergy between ozone therapy and the reduction of the inflammatory component due to epigenetic factors is essential to maintain favorable results in the medium and long term.