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- IRMS - Nicolae Testemitanu SUMPh
- 1. COLECȚIA INSTITUȚIONALĂ
- MedEspera: International Medical Congress for Students and Young Doctors
- MedEspera 2024
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/28770
Title: | Circadian rhythm disturbances and immune system |
Authors: | Hagag, Lee |
Keywords: | circadian rhythm;immune system;sleep disruption;clock genes;cytokines;melatonin;cortisol;shift work;immune regulation;inflammatory response |
Issue Date: | 2024 |
Publisher: | Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova |
Citation: | HAGAG, Lee. Circadian rhythm disturbances and immune system. In: MedEspera: the 10th Intern. Medical Congress for Stud. and Young Doctors, 24-27 April 2024: abstract book. Chișinău, 2024, p. 364. ISBN 978-9975-3544-2-4. |
Abstract: | Introduction. The intricate dance between the immune system (IS) and circadian rhythm (CR)
orchestrates a finely tuned symphony within the human body. IS is the body's vigilant defender against
pathogens, relying on innate and adaptive components for immediate and targeted responses. The study
aims to investigate the impact of circadian rhythm disturbances on immune system dynamics.
Aim of study. CR driven by the master circadian clock, regulates the rhythmic oscillations of
physiological and behavioral processes over 24 hours and synchronizes various bodily functions,
including sleep-wake cycles, hormone secretion, and metabolic activity. Also, immune cells exhibit
circadian oscillations, influencing the body's susceptibility to infections, and conversely, immune
challenges can disrupt CR. Understanding the nuances of this reciprocal relationship opens avenues
for exploring how CR disturbances may impact immune responses and vice versa, shedding light on
potential implications for human health and innovative therapeutic interventions.
Methods and materials. This systematic review synthesizes data from publications over the last
decade, sourced from PubMed, PMC, and Google Scholar, focusing on the intricate relationship
between normal and disturbed and the innate and adaptive ISN by analyzing approximately 51 relevant
studies. The following keywords were used for the search: circadian rhythm, immune system, sleep
disruption, clock genes, cytokines, melatonin, cortisol, shift work, immune regulation, and
inflammatory response.
Results. CR influences the innate and adaptive IS. It has been demonstrated that circadian clock
proteins play a significant role in T cell differentiation. For example, CD4+ T exhibits a rhythmic
expression of clock genes, and the circulation of B and T cells increases at night and decreases
throughout the day as they undergo extravasation. Cortisol, which peaks in the morning, stimulates
wakefulness but, when chronically high, can inhibit the immune system. Melatonin, which rises in the
evening, regulates the circadian rhythm and has anti-inflammatory properties, helping to maintain a
healthy immune response during sleep. Sleep disruptions reduce the immune system's response by
boosting cortisol and decreasing melatonin, increasing susceptibility to infections, encouraging
inflammation, and limiting wound healing. Prioritizing healthy sleep patterns is critical for overall
immune function support.
Conclusion. The circadian rhythm controls immunological responses by affecting clock gene
expression, cytokine production, immune cell activity and levels of hormones like cortisol and
melatonin. Coordination like this ensures an efficient and effective immunological response. Immune
modulation may be impacted by disruptions to the circadian rhythm, emphasizing the significance of
preserving a normal sleep-wake cycle. |
metadata.dc.relation.ispartof: | MedEspera: The 10th International Medical Congress for Students and Young Doctors, 24-27 April 2024, Chișinău, Republic of Moldova |
URI: | https://medespera.md/en/books?page=10 http://repository.usmf.md/handle/20.500.12710/28770 |
ISBN: | 978-9975-3544-2-4 |
Appears in Collections: | MedEspera 2024
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