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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7854
Title: Состояние антиоксидантной и оксидантной системы у больных ревматизмом и наследственными коллагенопатиями
Other Titles: Status of antioxidant and oxidant systems in rheumatic fever and hereditary collagen dysplasias
Authors: Azizova, X.H.
Askerova, T.A.
Mamedova, B.M.
Keywords: antioxidant system;rheumatic fever;hereditary collagen dysplasias;malondialdehyde;superoxide dismutase;catalase
Issue Date: 2013
Publisher: Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”
Citation: AZIZOVA, X. H., ASKEROVA, T. A., MAMEDOVA, B. M. Состояние антиоксидантной и оксидантной системы у больных ревматизмом и наследственными коллагенопатиями. In: Curierul Medical. 2013, vol. 56, no 6, pp. 54-57. ISSN 1875-0666.
Abstract: Recently, the interest in research on the role of free radical-induced lipid peroxidation reactions in pathogenesis of rheumatic fever and hereditary collagen dysplasias has considerably grown. The study tested blood plasma of 60 children: 18 carriers of hereditary collagen dysplasias and 42 children with rheumatic fever. Twenty healthy individuals have constituted control group. All patients have undergone complex clinical and laboratory examinations to evaluate process activity and disease stage, their familial and genealogical histories have been taken. Presence of rheumatoid factor was determined by latex agglutination test. Other rheumatic fever markers were tested by common methods. Status of the lipid peroxidation process was assessed by malondialdehyde content, using reaction with thiobarbituric acid and subsequent spectrophotometric measurement. Catalase activity was measured spectrophotometrically. To diagnosticate hereditary collagen dysplasias, hydroxyproline levels in blood and urine were assayed. Content of glycosaminoglycans was determined by electrophoresis, and levels of amino acids were measured chromatographically. In the majority of patients, the tests detected an increased daily urinary excretion of hydroxyproline and glycosaminoglycans what reflects the process of collagen metabolism disorders. The authors detected elevated levels of malondialdehyde, increased activity of superoxide dismutase and decreased activity of glutathione peroxidase and catalase. These three markers are sufficiently sensitive to assess affection of immunocompetent cells in rheumatic fever and hereditary collagen dysplasias.
URI: http://repository.usmf.md/handle/20.500.12710/7854
http://moldmedjournal.md/wp-content/uploads/2016/09/75.pdf
ISSN: 1875-0666
Appears in Collections:Curierul Medical, 2013, Vol. 56, Nr. 6



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