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http://repository.usmf.md:80/handle/20.500.12710/701
2024-03-29T06:31:45ZClinical and evolutive features of gouty arthritis
http://repository.usmf.md:80/handle/20.500.12710/24430
Title: Clinical and evolutive features of gouty arthritis
Authors: Rotaru, Larisa; Groppa, Liliana; Russu, Eugeniu; Codreanu, C.; Spinei, Larisa; Arnaut, Oleg; Nurseitova, Tamilla; Sarbu, Oxana; Vîzdoagă, Anatolie; Cornea, Cornelia
Abstract: Introduction. Gout is a disease that may be associated with different comorbidities, which causes difficulties in their management and appreciation of clinical manifestations.
The objective of the study was to analyse the clinical and evolution peculiarities in patients with gout, from different age groups.
Material and methods. A descriptive, selective study of 237 patients with gout (mean age of men 60±8.0 years and 63±9.0 years in women) was conducted. The diagnosis of gout was carried out according to the American College of Rheumatology and European League Against Rheumatism 2015 criteria. The patients were separated into two groups, depending on the age at the gout onset: <59 years (group I, 91 patients) and > 60 years (group II, 146 patients). The raw data were processed in SPSS version 26.0.
Results. The mean duration of the disease was comparable in both groups: 11 [7.6; 18.6] years (from 1 month to 23.7 years (p = 0.7) in group I and 11.3 [8.3; 14] years (from 1.6 years to 21.8 years) in group II. The equivalent duration of arthritis allowed comparing the characteristics of evolution in the groups. The chronic form of gout arthritis was slightly more common in group II than in group I, with significant differences (24% and 34%, p<0.01).
Conclusions. With the increase of age, the frequency of risk factors for gout increases: taking small doses of acetylsalicylic acid increases from 6 to 40%, diuretics from 18 to 44%, alcohol intake from 14 to 28%, hypertension from 44 to 78%, consumption of saturated foods with purine from 51 to 68%, overweight and obesity from 58 to 76% in the groups of patients with gout onset at the age less then 60 years and 60 years and more.2022-01-01T00:00:00ZCharacteristics of clinical manifestations of gout in the elderly people
http://repository.usmf.md:80/handle/20.500.12710/24428
Title: Characteristics of clinical manifestations of gout in the elderly people
Authors: Rotaru, Larisa; Groppa, Liliana; Codreanu, Catalin; Spinei, Larisa; Arnaut, Oleg; Russu, Eugeniu; Nistor, Alesea; Dutca, Lucia; Pamfil, Cristina; Cornea, Cornelia
Abstract: Introduction. Gout in elderly patients is characterized a pronounced comorbid background [2,8-10], which causes
difficulties in their management [9].
Objectives of the study. Analysis of the comorbid background for gout in different age groups. Identification of risk factors
characteristics, the onset and evolution of gout in elderly people compared to middle-aged patients.
Material and methods. To achieve the goal of the cross-sectional study, 237 patients with gout (average age for the men
60±8.0 years and for the women 63±9.0 years) were examined.
Results. The patients were separated into two groups, depending on the age of onset of gout: the age of onset up to and
including 59 years (group I, 146 people) and the age of onset after 60 years inclusive (group II, 91 people). The average
age in group I was 58.1±11.7 years, in group II - 72.8±4.1 years (p<0,1).
Conclusions. The average number of concomitant diseases is 2 times higher in the group of gout patients aged 60 years
and older (4.0 [3.0; 5.0]) than in the group of patients with gout under the age of 59 years inclusive (2.0 [2.0;3.0], p <0,1),
in patients with the onset of gout at the age of 59 years inclusive, the development of coronary artery disease, chronic
heart failure and nephrolithiasis occurs significantly earlier than in patients with the onset of gout at the age of 60 years
and older (48,4±6,9 years and 59,1±5,0 years; 53,6 ± 3,4 years and 65,6±9,0 years; 37,3±8,9 years and, respectively,
54,9±14,6 years, p<0,05 in all cases).2022-01-01T00:00:00ZAfectarea renală în gută
http://repository.usmf.md:80/handle/20.500.12710/24426
Title: Afectarea renală în gută
Authors: Rotaru, Larisa; Groppa, Liliana; Russu, Eugeniu; Chişlari, Lia; Deseatnicova, Elena; Cazac, Victor
Abstract: Asociaţiile între gutăşi bolile renale au fost deja de mult timp recunoscute. Scopul lucrăriia fost studierea particularităţi-lor clinice şi de evoluţie în timp a afectării renale la pacienţii cu gută. Au fost selectaţi analizei un număr de 50 de pacienţi cu gută în perioada anilor 2014-2016. A fost depistat că nefropatia cronică gutoasă are o evoluţie cu agravare în timp şi nefrolitiaza urică este cea mai frecventă manifestare renală a gutei. Profilaxia maladiilor renale este primordială în gută, deoarece disfuncţia renală duce la scăderea excreţiei acidului uric, şi astfel se creează un cerc vicios în evoluţia gutei.; Associations between gout and renal diseases have been already for a long time recognized. The purpose of this paper was to study the clinical particularities and evolution over time of renal disease in patients with gout. They have been selected for analysis a total of 50 patients gout in the period of 2014-2016. Have been found that nephropathy chronic gouty has an evolution with worsening in time and nephrolithiasis uric is the most common manifestation of renal gout. Prophylaxis of diseases kidney is paramount in gout, because the renal dysfunction leads to decreased excretion of uric acid, and this creates a vicious circle in the development of gout.; Взаимосвязь между подагрой и заболеваниями почек была уже давно известна. Целью исследования было изучениеклинических особенностей и динамик у поражения почек при подагре. Были проанализированы 50 пациентов с подагрой за период 2014-2016. Было выявлено,
что хроническая подагрическая нефропатия со временем прогрессирует и уратный нефролитиаз является наиболее частым проявлением поражения почек при подагре. Профилактика заболеваний почек имеет первостепенное значение при подагре, так как дисфункция почек ведет к снижению экскреции мочевой кислоты, и таким образом создается порочный круг в развитии подагры.2017-01-01T00:00:00ZAfectarea sistemului cardiovascular în gută
http://repository.usmf.md:80/handle/20.500.12710/24425
Title: Afectarea sistemului cardiovascular în gută
Authors: Rotaru, Larisa; Groppa, Liliana; Russu, Eugeniu; Chişlari, Lia; Sârbu, Oxana; Cazac, Victor
Abstract: Afectarea sistemului cardiovascular în gută este determinat de ateroscleroza vaselor şi hipertensiunea arterială, acestea fiind determinate de sindromul metabolic şi hiperuricemie. Scopul lucrăriia fost studierea factorilor de risc, particularităţilor clinico-evolutive şi de diagnostic la pacienţii cu afecţiuni cardiovasculare în gută. În perioada 2013-2016 au fost analizate 80 de pacienţi cu guta, dintre care 10 au fost de sex feminin şi 70 de sex masculin. A fost depistat că pe fon de gută: HTA - este stabilită la 73% din pacienţi, dislipidemiile la 60% din pacienţi. Diagnosticarea afectărilor cardiovasculare precoce permite profi laxia complicaţiilor care apar în cadrul gutei.; Impairment of the cardio-vascular system in gout is caused by atherosclerosis of the vessels and the hypertension, they are determined by metabolic syndrome and hyperuricemia. The purpose of this paper was to study the risk factors, peculiarities of the clinical-evolutionary and diagnostic in patients with cardio-vascular disorders in gout. In the 2013-2016 period were analyzed of 80 patients with gout, of which 10 were female and 70 male. It was found that on the gout: hypertension - is set at 73% of the patients, dyslipidemia in 60% of patients. Diagnosis cardio-vascular early allows for prevention of the complications that arise in the context of gout.; Поражение сердечно-сосудистой системы при подагре определяется атеросклерозом сосудов и артериальной гипертензией, которые обусловлены метаболическим синдромом и гиперурикемией. Целью исследования было изучение факторов риска, особенностей клинического течения, эволюции и диагностики у пациентов с заболеваниями сердечно-сосудистой системы при подагре. За период 2013-2016 были проанализированы 80 пациентов с подагрой, из которых 10 были женщины и 70 мужчин. Было выявлено, что на фоне подагры: гипертония - у 73% пациентов, дислипидемия у 60% пациентов. Ранняя диагностика поражения сердечно-сосудистой системы позволяет проводить профилактику осложнений, возникающих в ходе подагры.2017-01-01T00:00:00Z