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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/1168
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dc.contributor.authorGhicavii, Victor
dc.contributor.authorBacinschi, Nicolae
dc.contributor.authorPodgurschi, Lilia
dc.contributor.authorTurcan, Lucia
dc.contributor.authorChianu, Marin
dc.date.accessioned2019-04-09T10:48:53Z
dc.date.available2019-04-09T10:48:53Z
dc.date.issued2018
dc.identifier.citationGHICAVII, Victor, BACINSCHI, Nicolae, PODGURSCHI, Lilia, TURCAN, Lucia, CHIANU, Marin. Selection of antihypertensive drugs from the perspective of clinical pharmacology. In: The Moldovan Medical Journal. 2018, vol. 61, no 1, pp. 18-23. ISSN 2537-6373.en_US
dc.identifier.issn2537-6373
dc.identifier.issn2537-6381
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/1168
dc.identifier.urihttps://doi.org/10.5281/zenodo.1186184
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2019/01/moldmedjournal-2018-61-1-full-issue.pdf
dc.descriptionDepartment of Pharmacology and Clinical Pharmacology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldovaen_US
dc.description.abstractBackground: The rational use of medicines remains one of the most important directions of public health, especially in socio-medical diseases, including arterial hypertension. Material and methods: The study involved 28 cardiologists and 84 internists who, based on a set of questionnaires, expressed their opinion on ambulatory treatment of patients with arterial hypertension. Also 21 internists, 6 cardiologists and 6 obstetrician-gynecologists expressed their opinion on treatment of pregnancy-induced hypertension. Results: Cardiologists and internists recommended angiotensin-converting-enzyme inhibitors (ACE inhibitors) in 28% of cases, diuretics – in 23% of cases, beta-blockers (BB) – in 20, 4% of cases, calcium channel blockers (CCB) – in 13.7% of cases, angiotensin receptor blockers (ARB) – in 13.6% of cases for ambulatory treatment of patients with arterial hypertension. The antihypertensive drugs from other pharmacological groups (with central action, alpha-blockers, arteriodilators, sympatholytics, etc.) were prescribed in only 1.3% of patients. On treatment of hypertension in pregnancy showed that all physicians – 100% recommended as first-line agent for treatment of hypertension during pregnancy centrally acting antihypertensive drug Methyldopa. For second-line treatment they recommended CCB – in 36.36% of cases, alpha-adrenoblockers – in 24.24% of cases, BB – in 21.21% of cases, diuretics – in 12.12% of cases and 3% for ACE inhibitors and ARB. For treatment pre-eclampsia and eclampsia seizures in 84.85% of cases is recommended Magnesium sulfate and 15.15% mention labetalol, hydralazine and sodium nitroprusside. Conclusions: ACE inhibitors, diuretics, BAB, CCB and ARB have been first-line drugs in the arterial hypertension (AHT) treatment. For treatment of pregnancy-induced hypertension physicians recommended centrally acting antihypertensive drug Methyldopa. For second-line treatment they recommended calcium channel blockers (CCB), alpha-adrenoblockers, beta-blockers (BB) and diuretics. As third-choice in treatment of severe hypertension in preeclampsia are selected direct vasodilators as hydralazine, labetalol, sodium nitroprusside, and the most widely used in preeclampsia and eclampsia remains magnesium sulfate.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journal
dc.subjectarterial hypertensionen_US
dc.subjectantihypertensive drugsen_US
dc.subjectangiotensin-converting-enzyme inhibitorsen_US
dc.subject.ddcUDC: 615.225.2.035.1
dc.subject.meshAntihypertensive Agents--therapeutic useen_US
dc.subject.meshHypertension--drug therapyen_US
dc.subject.meshAntihypertensive Agents--pharmacologyen_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors--therapeutic useen_US
dc.subject.meshDiuretics--therapeutic useen_US
dc.subject.meshAdrenergic beta-Antagonists--therapeutic useen_US
dc.titleSelection of antihypertensive drugs from the perspective of clinical pharmacologyen_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal, Vol. 61, No 1, February 2018

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