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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/11807
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dc.contributor.authorHomițchi, Marinela
dc.date.accessioned2020-09-30T07:14:34Z
dc.date.available2020-09-30T07:14:34Z
dc.date.issued2020
dc.identifier.citationHOMIȚCHI, Marinela. Family of colecistokinetic peptides. In: MedEspera: the 8th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2020, p. 274.en_US
dc.identifier.urihttps://medespera.asr.md/wp-content/uploads/ABSTRACT-BOOK.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/11807
dc.descriptionDepartment of Biochemistry and Clinical Biochemistry, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020en_US
dc.description.abstractIntroduction. Cholecystokinin (CCK) is a peptide hormone that, together with secretin and gastrin, forms the triad of intestinal hormones. Due to the receptors, which are expressed in different tissues, and to the diversity of the subgroups of the cholecystokinin family peptides that activates them, CCK acts on different organs and systems.Aim of the study. Identification and study of the biochemical and physiological effects of the subgroups of the CCK peptides family and of their role in maintaining homeostasis and viability of the human organism. Materials and methods. A bibliographic study of the specialized literature present in the databases PubMed, MeSH, Internet Archive, IUPHAR/BPS, from 2010-2020 was performed, using the search words cholecystokinin, CCK receptors, expression of CCK receptors, cholecystokinin-like peptides, physiology of the Gastrointestinal Tract. Results. There are two types of CCK receptors: CCK-A (CCK1 "Alimentary") and CCK-B (CCK2 "Brain"). CCK-A receptors are located in the gall bladder where stimulates its contractions, in the intestinal parietal mucosa where via somatostatin inhibits gastric acid secretion, in the nervous system where directly or indirectly, through dopaminergic processes, it modulates the behavior in general and eating behavior in particular. CCK-B receptors are predominantly in the CNS where they modulate anxiety, analgesia and neuroleptic activities. CCK-B receptors also have been identified in the pancreas where they stimulate the secretion of enzymes. It has been shown that pancreas-responsible neurons release CCK-8 and CCK-5, which subsequently produce effects. Moreover, CCK via acetylcholine activates parasympathetic neurons, therefore increasing blood supply to the stomach and increasing motility. At the thyroid level, CCK-8 stimulates normal growth and C-cell proliferation. Conclusions. The expression of CCK at the level of different organs determines a wide range of various effects, involved in normal metabolic and physiological processes, which ensures the maintenance of homeostasis and viability of organs and tissues. Knowledge of the pleiotropic effects of the CCK family peptides and the receptors involved in their development opens new possibilities for addressing the nutritional disorders and functional diseases of the gastrointestinal tract, as well as of intervention in some processes in the nervous system associated with chronic pain, anxiety and depression.en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectcholecystokininen_US
dc.subjectcholecystokinin family peptidesen_US
dc.subjectCCK-A CCK-B receptorsen_US
dc.titleFamily of colecistokinetic peptidesen_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2020

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