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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12123
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dc.contributor.authorGrigoriev, Valeria-
dc.date.accessioned2020-10-12T18:53:00Z-
dc.date.available2020-10-12T18:53:00Z-
dc.date.issued2016-
dc.identifier.citationGRIGORIEV, Valeria. Polarimetry as a method used in quality control of different pharmacotherapeutic groups chiral drugs. In: MedEspera: the 6th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2016, pp. 338-339.en_US
dc.identifier.isbn978-9975-3028-3-8.-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12123-
dc.descriptionDepartment of pharmaceutical and toxicological chemistry, Nicolae Testemitanu State University ofMedicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016en_US
dc.description.abstractIntroduction: Chiral compounds that are found in all pharmacotherapeutic groups, and represent a major potential in curing degenerative diseases possesses the property to rotate the plane of polarization of light, so they are optically active phenomenon that can be observed and investigated using a polarimeter. Polarimetric method is widely used in pharmaceutical analysis for determining the optical activity of drug substances, their quantitative and qualitative assessment. The purpose of this paper is to estimate the importance, actuality and usefulness of polarimetric method in the analysis of chiral drugs from different pharmacotherapeutic groups. Materials and methods: In order to determine statistically the rate of recommendation of polarimetric method in the research of drug substances by various states pharmacopoeia, to highlight the benefits of polarimetric method was performed meta-analysis of Romanian Pharmacopoeia ed. X (FR), the European Pharmacopoeia 8th ed. (Ph. Eur.), United States Pharmacopoeia 2nd ed. (Ph. USP), British Pharmacopoeia 2013 (BPH.), The information published in specialized periodicals. Results: In FR ed. X there are 83 drug substances using specific rotatory power is an index of quality, which constitute 12.77% of the total number of substances. For comparison, in European Pharmacopoeia this number is about 15.3 times higher. However, the use of this physical constant for quantitative determinations of is quite limited and this despite the fact that polarimetry as an optical method polarimetry can be used successfully in dosing chiral drug substances. Conclusion: There is a great number of pharmaceutical substances with optical properties included in pharmacopoeia. Polarimetric method can be proposed as an alternative for the dosage of various pharmacotherapeutic groups chiral substances, as a quick, accessible, accurate and nondestructive method.en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectchiral drugsen_US
dc.subjectpolarimetryen_US
dc.subjectpolarimeteren_US
dc.subjectoptic methoden_US
dc.subjectquality controlen_US
dc.subjectPharmacopoeiaen_US
dc.titlePolarimetry as a method used in quality control of different pharmacotherapeutic groups chiral drugsen_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2016



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