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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/1216
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dc.contributor.authorTimercan, Tatiana
dc.date.accessioned2019-04-16T12:17:03Z
dc.date.available2019-04-16T12:17:03Z
dc.date.issued2018
dc.identifier.citationTIMERCAN, Tatiana. A modern approach to interleukin-6. In: The Moldovan Medical Journal. 2018, vol. 61, no 3, pp. 47-52. ISSN 2537-6373.en_US
dc.identifier.issn2537-6373
dc.identifier.issn2537-6381
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/1216
dc.identifier.urihttps://doi.org/10.5281/zenodo.1299041
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2019/01/moldmedjournal-2018-61-3-full-issue.pdf
dc.descriptionDepartment of Biochemistry and Clinical Biochemistry, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldovaen_US
dc.description.abstractBackground: Interleukin-6 is a multifunctional cytokine with well-defined pro- and anti-inflammatory properties. Binding to the receptor complex composed of specific interleukin-6-receptor (IL-6R) and transmembrane glycoprotein gp130, it stimulates various signalling cascades. Intracellular signal transduction involves both STAT-dependent, and STAT-independent mechanisms. IL-6R exists in the soluble and the membrane-bound forms, thus were described the classical signalling and the trans-signalling pathways. The pro-inflammatory response occurs via trans-signalling, while the antiinflammatory effects are mediated by classical signalling pathway. IL-6 is produced by cardiovascular components. The high levels of IL-6 are identified in the inflammatory diseases. Conclusions: IL-6 expresses the well-defined pro- and anti-inflammatory properties. The experimental studies have revealed classic signalling pathway with regenerative and anti-inflammatory effects (via the membrane-bound IL-6R), and trans-signalling responsible for the pro-inflammatory response (via the soluble form sIL-6R). The intracellular signal transduction involves the activation of STATs, MAPK, and PI3K cascades. It has been proved that in the cardiovascular pathologies the serum levels of IL-6 correlate with the disease severity and the degree of myocardial damage, being the indicator of heart disease and a predictive factor of adverse outcomes.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journal
dc.subjectinterleukin-6en_US
dc.subjectcytokineen_US
dc.subjecttrans-signallingen_US
dc.subjectcardiac ischemiaen_US
dc.subject.ddcUDC: 577.112.6
dc.subject.meshInterleukin-6en_US
dc.subject.meshCytokinesen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshCell Movementen_US
dc.subject.meshApoptosisen_US
dc.subject.meshGlycoproteinsen_US
dc.titleA modern approach to interleukin-6en_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal, Vol. 61, No 3, October 2018

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