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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12330
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dc.contributor.authorBotezatu, Adriana
dc.contributor.authorBodrug, Nicolae
dc.contributor.authorIstrate, Viorel
dc.date.accessioned2020-10-26T22:40:39Z
dc.date.available2020-10-26T22:40:39Z
dc.date.issued2020
dc.identifier.citationBOTEZATU, Adriana, BODRUG, Nicolae, ISTRATE, Viorel. Precancerous gastric lesions: pathophysiology and symptomatology. In: The Moldovan Medical Journal. 2020, vol. 63, no 5, pp. 62-67. ISSN 2537-6381. DOI: 10.5281/zenodo.4018962en_US
dc.identifier.isbn2537-6381
dc.identifier.isbn2537-6373
dc.identifier.urihttps://doi.org/10.5281/zenodo.4018962
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2020/10/63-5-Spaltul-7-din-01-10-20.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12330
dc.descriptionDepartment of Internal Medicine, Discipline of Geriatrics and Occupational Diseases Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, Medical Center ”Excellence”, Chisinau, the Republic of Moldova, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)en_US
dc.description.abstractBackground: Independent risk factors for chronic atrophic gastritis, gastric intestinal metaplasia and gastric cancer are: Helicobacter pylori infection (especially virulent CagA strains), genetic factors (advanced age, reflecting the duration of Helicobacter pylori infection, male gender, family history of gastric cancer in first-degree relatives), gastric ulcer, biliary reflux, acute or chronic gastric inflammation, smoking, alcohol consumption, prolonged use of proton pump inhibitors or non-steroidal anti-inflammatory drugs, diet low in fruits, vegetables and vitamin C, excessive salt intake and consumption of canned foods with salt). Helicobacter pylori infection and inflammatory cells induce the expression of inducible nitric oxide synthase in the gastroduodenal mucosa, which causes various clinical lesions (duodenal ulcer, gastric ulcer and chronic gastritis without ulcer). Another important condition associated with Helicobacter pylori infection is gastric cancer. Overproduction of nitric oxide, through inducible nitric oxide synthase and oxidative stress, is a genotoxic and mutagenic metabolism which plays a crucial role in the process of gastric carcinogenesis. Conclusions: Chronic atrophic gastritis is considered a multifaceted condition because it can manifest itself through a variable spectrum of nonspecific gastric and extra-gastric symptoms, with an overlap of the clinical features of the two entities of chronic atrophic gastritis – autoimmune and associated with Helicobacter pylori infection. Thus, in contrast to the classic perception of a silent condition, patients with chronic atrophic gastritis report a wide range of gastrointestinal symptoms, ranging from dyspeptic symptoms to those of gastroesophageal reflux.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journal: The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)
dc.subjectgastric intestinal metaplasiaen_US
dc.subjectepithelial dysplasiaen_US
dc.subjectgastric canceren_US
dc.subjectHelicobacter pylorien_US
dc.subject.ddcUDC: 616.33-002.27:579.835.12+616.33-006en_US
dc.titlePrecancerous gastric lesions: pathophysiology and symptomatologyen_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal, Vol. 63, No 5, November 2020

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