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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12826
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dc.contributor.authorRacoviță, Stela-
dc.contributor.authorMoșin, Veaceslav-
dc.contributor.authorCapcelea, Svetlana-
dc.contributor.authorMișina, Ana-
dc.contributor.authorCemortan, Igor-
dc.contributor.authorSprincean, Mariana-
dc.date.accessioned2020-11-10T12:53:39Z-
dc.date.available2020-11-10T12:53:39Z-
dc.date.issued2020-10-
dc.identifier.urihttps://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12826-
dc.description“Nicolae Testemitanu” State University of Medicine and Pharmacy, Institute of Mother and Child, Chisinau, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareen_US
dc.description.abstractBackground: Male infertility is a heterogeneous disorder with a substantial genetic basis. The most common genetic causes of male infertility are chromosomal anomalies and microdeletions of the azoospermia factor (AZF). The frequency of these chromosomal anomalies increases in azoospermic men. Purpose: To assess chromosomal variations in males with azoospermia in order to confirm the importance of the cytogenetic testing for diagnosis and treatment assessment. Methods: We performed cytogenetic analysis in a group of 128 infertile men with azoospermia from the Republic of Moldova during 2013-2018 period.  Karyotyping was performed on peripheral blood lymphocytes according to standard methods G-banding of metaphase chromosomes. For reporting the results, the 2016 International System of Cytogenetic Nomenclature was used. Results: 128 men with azoospermia were cytogenetically investigated in 2013- 2018 at the department of the National Center for Reproductive Health and Medical Genetics (Table 1). We identified that from 128 azoospermic cases, 80 (62%) had normal karyotype (46,XY) and 48 (38%) showed variations in the number or structure of chromosomes. 38 patients (30%) showed variations in the X or Y sex chromosomes, and 10 patients (8%) had variations in the autosomal chromosomes (Figure 4, Table 1, 2, 3). Conclusions: Cytogenetic investigations for men with severely affected spermiogram is important for the etiologic diagnosis of male infertility with clinical relevant in treatment, as well as assessment and prognosis. The occurrence (38%) of chromosomal variations among infertile males strongly suggests genetic testing prior to ART.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu"en_US
dc.subjectmale infertilityen_US
dc.subjectazoospermiaen_US
dc.titleCytogenetic analysis in males with azoospermiaen_US
dc.typeOtheren_US
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