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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12853
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dc.contributor.authorPodgornii, Ana-
dc.contributor.authorValica, Vladimir-
dc.contributor.authorPogrebnoi, Serghei-
dc.contributor.authorLupascu, Lucian-
dc.contributor.authorUncu, Andrei-
dc.contributor.authorMacaev, Fliur-
dc.date.accessioned2020-11-11T07:40:18Z-
dc.date.available2020-11-11T07:40:18Z-
dc.date.issued2020-10-
dc.identifier.urihttps://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12853-
dc.descriptionDepartment of Pharmaceutical and Toxicological Chemistry, Drug Scientific Center Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, Laboratory of Organic Synthesis and Biopharmaceuticals, Institute of Chemistry, Chisinau, the Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareen_US
dc.description.abstractIntroduction. The therapeutic options in invasive candidiasis and aspergillosis are limited and don’t provide expected results. Introducing a new drug in the therapeutic practice can improve the quality of life of immunocompromised patients. The compound have poor solubility in polar solvents (water, methanol, ethanol, acetonitrile, acetone) and low bioavailability that limits the use as antitubercular agent. But, presence of the azole ring (pharmacophore group of azole antimycotic drug) suggests that the studied substance may have antimycotic activity. Purpose. The aim is to study the antimycotic activity of new substance phenoxithiazolchloralum (MF0010) on Aspergillus spp., Candida albicans, and Saccharomyces cerevisiae. Material and methods. Aspergillus spp. For the evaluating of the antifungal activity of the phenoxythiazolchloralum compound against Aspergillus spp. it was used the microdilution method described by E. Stingaci et al.(Stingaci E, Zveaghinteva M, Pogrebnoi S, Lupascu L, Valica V, Uncu L, Smetanscaia A, Drumea M, Petrou A, Ciric A, Glamoclija J, Sokovic M, Kravtsov V, Geronikaki A, Macaev F. New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters. 2020;30(17). DOI:10.1016/j.bmcl.2020.127368). Candida albicans and Saccharomyces cerevisiae For the evaluating of the antifungal activity for Candida albicans, and Saccharomyces cerevisiae was used the successive double dilution method (NCCLS M27). Results. For the first time, it was studied in vitro susceptibility of MF-0010 against A. fumigatus, A. versicolor, A. ochramensis and A. niger. The MIC and MFC values of MF-0010 against Aspergillus spp. ranged from 0.23μM/ml – 0.62μM/ml and 0,62μM/ml –1.24μM/ml, respectively. The highest values of MIC and MCF of MF-0010 is related to A. niger. Thus, the use of MF-0010 against this pathogen is not appropriate. With at least 0.05 μM/ml difference of MICs from standards, MF-0010 can be considered quite more potent than ketoconazole and bifonazole. The MIC/MCF ratios of MF-0010 for inhibition of Candida albicans, Saccharomyces cerevisiae of are lower than nistatine ones with 0.08 μMol for both pathogens. Thus, we can conclude that MF-0010 is more potent active molecule than nistatine against Candida albicans. Conclusions. In this study, we found that all analyzed pathogens were susceptible to MF-0010. According to experimental data, the antimycotic activity of MF-0010 is quite better than the standards one. The MIC and MCF values of MF-0010 show a good potency against Candida albicans, and new studies are warranted in order to design optimized formulations, to analyse in vivo efficacy and quality assurance of formulations.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu"en_US
dc.subjectPhenoxythazolchloralumen_US
dc.subjectAspergillus spp.en_US
dc.subjectCandida albicansen_US
dc.subjectSaccharomyces cerevisiaeen_US
dc.subjectdrug discoveryen_US
dc.titleAntimycotic activity of phenoxythiazolchloralumen_US
dc.typeOtheren_US
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