USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/13051
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLazăr, Cornelia
dc.contributor.authorVozian, Marin
dc.contributor.authorPantea, Valeriana
dc.contributor.authorSvet, Inna
dc.contributor.authorMishina, Anna
dc.contributor.authorTagadiuc, Olga
dc.date.accessioned2020-11-18T12:22:01Z
dc.date.available2020-11-18T12:22:01Z
dc.date.issued2019
dc.identifier.citationLazăr, Cornelia, Vozian, Marin, Pantea, Valeriana, [et al]. The effect of controlled reperfusion on experimental ovarian torsion. In: Russian Open Medical Journal. 2019, vol. 8, no 4 (december). DOI: 10.15275/rusomj.2019.0404en_US
dc.identifier.issn2304-3415
dc.identifier.uriDOI: 10.15275/rusomj.2019.0404
dc.identifier.urihttps://romj.org/2019-0404
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/13051
dc.descriptionNicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova; Mother and Child Institute, Chisinau, Republic of Moldova.en_US
dc.description.abstractThe objective of our research was to study the effect of controlled reperfusion on lactate and advanced oxidation protein products (AOPP) in experimental ovarian torsion (OT), and to evaluate the possibility to reduce the reperfusion injuries applying the ON-OFF technique of reperfusion. Material and Methods — Lactate and AOPP were measured in serum and ovarian homogenates of 70 females rats, divided equally into 7 groups: no intervention (nr. 1); laparotomy (nr. 2); 3 hours OT (nr. 3); 3 hours OT + 1 hour (nr. 4) or 24 hours (nr. 6) of simple reperfusion (SR); 3 hours OT + 1 hour (nr. 5) or 24 hours (nr. 7) of controlled reperfusion (ON-OFF). The results were analyzed using Welch's ANOVA. Results — OT produced an increase of serum (66%, p<0.001) and homogenate (38%, p=0.006) lactate, that tended to return to baseline in 24 hours despite the type of reperfusion. AOPP had grown in OT animals serum (20%, p=0.007) and homogenate (26%, p>0.05) and continued to rise in the serum after SR, while in ON-OFF technique groups – decreased by about 20% (p<0.01). Homogenate AOPP levels rised after reperfusion in all groups. Conclusion — Lactate is a biomarker for ischemia in OT. Increased AOPP in experimental groups indicates that there is a degree of oxidative stress that can affect the cells after the restoration of the blood flow. Therefore, the correct management of the condition that reduces reactive oxygen species production, such as controlled method of reperfusion, could be appropriate to prevent additional injuries.en_US
dc.language.isoenen_US
dc.publisherRussian Open Medical Journalen_US
dc.subjectovarian torsionen_US
dc.subjectcontrolled reperfusionen_US
dc.subjectreperfusion injuryen_US
dc.subjectlactateen_US
dc.subjectadvanced oxidation protein productsen_US
dc.titleThe effect of controlled reperfusion on experimental ovarian torsionen_US
dc.typeArticleen_US
Appears in Collections:ARTICOLE ȘTIINȚIFICE

Files in This Item:
File Description SizeFormat 
romj_2019_0404.pdf234.4 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback