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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/13318
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dc.contributor.authorȚâmbală, Diana-
dc.contributor.authorBotnaru, Victor-
dc.contributor.authorMunteanu, Oxana-
dc.date.accessioned2020-11-26T12:26:10Z-
dc.date.available2020-11-26T12:26:10Z-
dc.date.issued2020-10-
dc.identifier.urihttps://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/13318-
dc.descriptionPneumology and Alergology Discipline, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareen_US
dc.description.abstractIntroduction: Thymomas are among the rare forms of mediastinal tumors, with more than 20 associated parathymic syndromes being described. The connection between autoimmune and thymoma manifestations has long been known, although the mechanisms involved are still a mystery. Methods and Materials: A case of a 41-year-old patient diagnosed with thymoma at the age of 30 is presented. Erythroblastopenia was confirmed by the reduction of erythrocyte series in bone marrow. Ulcerative colitis confirmed by histological examination. Thoracic HRCT (at age of 30-33-39-40 years; B, E, H, I) allowed pulmonary lesions assessment. Good’s syndrome was ruled out by normal serum immunoglobulins values. Results: The onset of the disease with low grade fever and retrosternal pain at age 27, misdiagnosed as pericarditis (mediastinal enlargement on chest X-ray) led to treatment with methylprednisolone. Pregnancy at 28 years old (birth of a healthy child) was the reason for the refusal of further examinations and surgical treatment, but contributed to the significant tumor growth with clinical manifestations of parathymic syndromes (erythroblastopenia with severe anaemia, ulcerative colitis), which did not disappear after thymectomy and splenectomy (over 2 years). Lung lesions have progressed from centrilobular nodules to bilateral extensive cystic bronchiectasis. Discussion: Around 1-8% of adults with bronchiectasis are diagnosed with humoral immune deficiency. Systemic inflammatory disorders or immune deficiencies, such as hypogammaglobulinemia or HIV infection is often related to be the cause of diffuse bronchiectasis. Patients that have thymic neoplasms sometimes may present with some thoracic symptoms or be clinically indolent. There are known multiple autoimmune parathymic syndromes associated with thymic neoplasms. Understanding the potential etiologies of bronchiectasis in thymic neoplasms helps the management of these patients. Thymomectomy should be an indication for these kind of patients in order to reduce the parathymic implications. Conclusions: The case illustrates rare forms of parathymic syndromes as well as the impact of thymectomy and splenectomy on their evolution. Thymoma-associated bronchiectasis predisposes to recurrent respiratory infections and progressive worsening of lung function, including in young patients.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu"en_US
dc.subjectbronchiectasisen_US
dc.subjectthymomaen_US
dc.subjecterythroblastopeniaen_US
dc.subjectcolitisen_US
dc.titleParathymic syndromes in a young patient with thymoma: bronchiectasis, erythroblastopenia and ulcerative colitisen_US
dc.typeOtheren_US
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