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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/13481
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dc.contributor.authorAndronache, Lilia
dc.date.accessioned2020-11-30T17:47:44Z
dc.date.available2020-11-30T17:47:44Z
dc.date.issued2016
dc.identifier.citationANDRONACHE, Lilia. Influence of new Schiff bases and their combinations with 3d metals on the glutathione and thiol-disulfide metabolism in the liver in physiological conditions. In: Curierul Medical. 2016, vol. 59, no 2, pp. 2-5. ISSN 1875-0666.en_US
dc.identifier.issn1875-0666
dc.identifier.issnhttp://moldmedjournal.md/wp-content/uploads/2016/09/Cm-2-0-2016-PDF-Integral-3.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/13481
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2016/09/Cm-2-0-2016-PDF-Integral-3.pdf
dc.description.abstractBackground: Glutathione and glutathione metabolism enzymes are essential for the normal functioning of cells and tissues and maintenance of body homeostasis. The aim of our study was to investigate the influence of the new Schiff bases, and their combinations with 3d metals, on the glutathione metabolism in the liver in physiological conditions. Material and methods: An experimental study of laboratory animals (rats) was performed. New local biologically active compounds (BAC) – CMD-4, CMD-8 and CMJ-23, were injected to healthy rats for 14 days. The content of glutathione (total, reduced and oxidized) and the activity of glutathione reductase (GR), glutathione peroxidase (GPO), glutathione-S-transferase (GST) and glutaredoxin (GRX) were determined in the liver homogenates. results: All tested BAC statistically significant decreased the level of reduced and total glutathione (about 20-30%), and GMJ-23 also reduced the oxidized glutathione in the liver (-48%, p<0.05). Influence on the activity of enzymes of glutathione metabolism was more ambiguous. Administration of CMD-4, CMD-8 and CMJ-23 did not produce conclusive changes of the enzyme activity of the glutathione metabolism, and their induction had only tendency of GR, GST and GRX activity decrease, while CMT-28 and CMT-67 preferentially modulated the activity of enzymes. conclusions: Local BAC exerts an individual influence on the glutathione metabolism in physiological conditions, which may be used for a particular regulation of the processes according to the cell needs.en_US
dc.language.isoenen_US
dc.publisherMinisterul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”en_US
dc.relation.ispartofCurierul Medical
dc.subjectSchiff basesen_US
dc.subject3d metalsen_US
dc.subjectglutathioneen_US
dc.subjectliveren_US
dc.titleInfluence of new Schiff bases and their combinations with 3d metals on the glutathione and thiol-disulfide metabolism in the liver in physiological conditionsen_US
dc.typeArticleen_US
Appears in Collections:Curierul Medical, 2016, Vol. 59, No 2



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