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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/14564
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dc.contributor.authorHotineanu, Adrian
dc.contributor.authorCazac, Anatol
dc.date.accessioned2021-01-05T10:56:58Z
dc.date.available2021-01-05T10:56:58Z
dc.date.issued2020
dc.identifier.citationHOTINEANU, Adrian, CAZAC, Anatol. Diagnosis and contemporary treatment of pancreatic insulinoma = Diagnostic şi tratament contemporan a insulinomului pancreatic. In: Congresul consacrat aniversării a 75-a de la fondarea USMF „Nicolae Testemițanu”, 21-23 octombrie 2020: Abstract book. Chișinău: [s. n.], 2020, p. 414.en_US
dc.identifier.urihttps://stiinta.usmf.md/sites/default/files/inline-files/Abstract%20Book.%20CULEGERE%20DE%20REZUMATE%20.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/14564
dc.description.abstractBackground. Insulinomas are rare neuroendocrine tumors developed from pancreatic islet β-cells and is a common cause of hypoglycemia due to endogenous hyperinsulinism. Medical topographic imagistic diagnosis is difficult to achieve due to the small tumor size. Objective of the study. Evaluation of modern diagnostic and curative strategies in pancreatic insulinoma. Material and Methods. The study presents the results of surgical treatment applied to 14 patients with pancreatic insulinoma (including a case of recurrent insulinoma over 8 years) during the years 1993-2019, within the Department of Surgery No.2. Diagnostic management included clinical, laboratory examination (assessment of serum insulin, glucagon, C-peptide), ultrasound, CT, MRI. Results. Neuropsychic symptoms(cases)-12(85,8%), adrenergic-10(71,4%), digestive-7(50,0%), Cushingoid syndrome-2(14,3%). Glycemic level during hypoglycemic and convulsive seizures: 2.1-3.1mmol/l, after administration of glucose 40%-3.6- 5.5mmol/l, mean value of insulin-32,17µU/Ml, peptide C-4 , 55ng / ml; sensitivity of the methods: ultrasound-32.3%, CT-50.0%, CT in angiographic regime-92,5%, MRI-90,0%. Surgery performed: tumor enucleation-5(41.7%), corporo-caudal pancreatectomy-9 (64.3%). Postoperative mortality0. Conclusion. Contemporary preoperative and intraoperative imagistic methods allow the localization and excision of insulinoma, avoiding blind pancreatic resections. Early surgery prevents the sequelae of hypoglycemic encephalopathy. Introducere. Insulinoamele sunt tumori dezvoltate din celulele β insulare pancreatice, cu incidență redusă, fiind cea mai frecventă cauză de hipoglicemie prin hiperinsulinism endogen. Diagnosticul topografic imagistic este dificil de realizat din cauza dimensiunilor tumorale mici. Scopul lucrării. Evaluarea strategiilor diagnostice şi curative moderne în insulinomul pancreatic. Material și Metode. Studiul prezintă rezultatele tratamentului chirurgical aplicat la 14 pacienţi cu insulinom pancreatic (inclusiv un caz de insulinom recidivant peste 8 ani), în perioada anilor 1993-2019, în cadrul Catedrei Chirurgie Nr.2. Managementul diagnosticului a inclus examenul clinic, de laborator (aprecierea nivelului insulinei serice, glucagon, peptidului C), ecografie, CT, IRM. Rezultate. Simptomele neuropsihice (cazuri)-12(85,8%), adrenergice-10(71,4%), digestive-7(50,0%), sindromul Cushingoid2(14,3%). Nivelul glicemic în timpul crizelor hipoglicemice şi convulsive: 2,1-3,1mmol/l, după administrarea glucozei 40% -3,6-5,5mmol/l, valoarea medie a insulinei – 32,17µU/Ml, peptidului C4,55ng/ml; sensibilitatea metodelor: ecografie-32,3%, CT-50,0%, CT în regim angiografic – 92,5%, IRM-90,0%. Intervenţiile chirurgicale efectuate: enuclearea tumorii- 5(41,7%), pancreatectomie corporo-caudală – 9(64,3%). Mortalitatea postoperatorie– 0. Concluzii. Metodele imagistice contemporane pre-intraoperatorii permit localizarea şi exereza insulinomului, evitând rezecţiile pancreatice oarbe. Intervenţia chirurgicală precoce previne sechelele de encefalopatie hipoglicemică.en_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldovaen_US
dc.subjectpancreatic insulinomaen_US
dc.subjectdiagnosisen_US
dc.subjecttreatmenten_US
dc.titleDiagnosis and contemporary treatment of pancreatic insulinomaen_US
dc.title.alternativeDiagnostic şi tratament contemporan a insulinomului pancreaticen_US
dc.typeOtheren_US
Appears in Collections:Congresul consacrat aniversării a 75-a de la fondarea USMF „Nicolae Testemițanu”, 21-23 octombrie 2020: Abstract book

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