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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/14649
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dc.contributor.authorAgapii, Mihaela-
dc.date.accessioned2021-01-05T21:28:29Z-
dc.date.available2021-01-05T21:28:29Z-
dc.date.issued2020-
dc.identifier.urihttps://stiinta.usmf.md/sites/default/files/inline-files/Abstract%20Book.%20CULEGERE%20DE%20REZUMATE%20.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/14649-
dc.description.abstractBackground. Covid-19 continues to surprise with the variety of symptoms it causes, which is manifested both by respiratory symptoms and by the involvement of the vascular endothelium. This pathology combines the harmful effects of generalized inflammation and coagulation disorders. Objective of the study. To determine the mechanisms by which the fusion of the SARSCoV2 virus takes place with the human host cells and by which it causes disorders of the blood coagulation for the argumentation of possible treatment strategies. Material and Methods. Analysis of clinical trials performed on patients with Covid-19 and also of the literature of 2020 through the following sources: Revmed, Sciencedirect, dovepress, medrxiv, lemonde, and 10 other bibliographic sources. Results. The main actors of SARS-CoV2 infection are the following types (N354D and D364Y, V367F, W436R) of spike proteins (RBDs) that show an increased affinity for the ACE2 receptor ((ΔG) significantly reduced), which allows the virus to bind easily to the surface of the host cell. Complement system, inflammation and coagulation - are interrelated, hypoxia, being caused by respiratory dysfunction, which triggers the "cytokine storm". It includes interferon, chemokine, TNF, interleukin, which together with elevated levels of D-dimers and fibrinogen, Willebrand factor, factor VIII show a procoagulant activity. Conclusion. The most severe clinical forms are associated with anomalies in hemostasis, especially the increase of the concentration of dimers D. Early detection of these potentially predictive anomalies would contribute to an optimized prescription of anticoagulant therapy, facilitating the treatment of pat. Introducere. Covid-19 continuă să surprindă prin varietatea de simptome provocate, care se manifestă atât prin simptomatologie respiratory, cât şi prin implicare a endoteliului vascular. În această patologie se combină efectele nocive ale inflamaţiilor generalizate şi ale tulburărilor de coagulare. Scopul lucrării. Determinarea mecanismelor prin care are loc fuziunea virusului SARS-CoV2 cu celulele umane gazdă și prin care provoacă dereglări ale coagulării sanguine pentru argumentarea unor eventuale strategii de tratament. Material și Metode. Analiza studiilor clinice efectuate asupra pacienţilor bolnavi de Covid-19 şi a literaturii anului 2020, prin intermediul următoarelor surse: Revmed, Sciencedirect, dovepress, medrxiv, lemonde şi alte 10 surse bibliografice. Rezultate. Principalii actori ai infecţiei cu SARS-CoV2 sunt următoarele tipuri (N354D şi D364Y, V367F, W436R) ale proteinelor spike (RBD) care manifestă o afinitate crescută pentru receptorul ACE2 ((ΔG) redusă semnificativ)), ceea ce permite virusului să se lege uşor de suprafaţa celulei gazdă. Sistemul complementului, inflamaţia şi coagularea sunt interrelaţionate, hipoxia cauzată de disfuncţia respiratorie declanşează ,,furtuna de cytokine” ce curpinde interferonul, chemokina, TNF, interleukina care împreună cu nivelurile crescute de D-dimeri şi fibrinogen, factorul Willebrand, factorul VIII prezintă o activitate procoagulantă. Concluzii. Cele mai severe forme clinice sunt asociate cu anomalii ale hemostazei, în special creşterea concentraţiei de dimeri D. Depistarea timpurie a acestor anomalii potenţial predictive ar contribui la o prescripţie optimizată a terapiei anticoagulante, facilitând tratamentul pacienţilor.en_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldovaen_US
dc.subjectSARS-CoV-2en_US
dc.subjectinflammationen_US
dc.subjecthemostasisen_US
dc.subjectSpikeen_US
dc.subjectACE2en_US
dc.titleCOVID-19 - inflammatory vascular diseaseen_US
dc.title.alternativeCOVID-19 - boală vasculară inflamatorieen_US
dc.typeOtheren_US
Appears in Collections:Congresul consacrat aniversării a 75-a de la fondarea USMF „Nicolae Testemițanu”, 21-23 octombrie 2020: Abstract book

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