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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/16638
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dc.contributor.authorCurac, Victor-
dc.contributor.authorPodgornîi, Ana-
dc.date.accessioned2021-04-11T09:20:08Z-
dc.date.available2021-04-11T09:20:08Z-
dc.date.issued2017-
dc.identifier.citationCURAC, Victor, PODGORNÎI, Ana. Obţinerea nanocristalelor de fenoxitiazolcloral = The production of the phenoxythiazolechloralum nanocrystals. In: Revista Farmaceutică a Moldovei. 2017, nr. 1-2, p. 29. ISSN 1812-5077.en_US
dc.identifier.issn1812-5077-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/16638-
dc.descriptionUniversitatea de Stat de Medicină şi Farmacie „NicolaeTestemiţanu” din Republica Moldovaen_US
dc.description.abstractIntroducere. Optimizarea biodisponibilităţii substanţelor medicamentase nou sintetizate este una din cele mai mari provocări în design-ul raţional al medicamentelor. Asigurarea unei solubilităţi acceptabile poate fi realizată prin obţinerea nanoparticulelor. Practic 80% din articolele ştiinţifice despre nanoparticule, demonstrează solubilitatea mărită a nanoparticulelor faţă de cea a substanţei brute. Fenoxitiazolcloralul a fost sintetizat în cadrul Institutului de Chimie şi reprezintă o substanţă antituberculoasă cu un înalt potenţial terapeutic, dar care posedă o solubilitate nesatisfacătoare. Astfel, se presupune că modificarea dimensiunilor parcticulelor prin nanonizare poate contribui la îmbunătăţirea acestui parametru. Scopul lucrării. Obţinerea nanocristalelor de fenoxitiazolcloral cu ajutorul tehnologiilor modeme. Material şi metode. Studiul şi analiza literaturii ştiinţifice despre obţinerea nanoparticulelor. Nanonizare prin măcinare uscată. Balanţa analitică OHAUS, Moară cu bile, Microscop Mikos. Fenoxitiazolcloral, PEG, Polisorbat 60. Rezultate. Au fost selectate cele mai relevante metode de producere a nanocristalelor, şi anume măcinarea uscată în moara cu bile şi omogenizarea la presiune înaltă. Au fost obţinute 6 probe de nanoparticule: 2 probe conţin PEG; 2 probe - Polisorbat 60 şi 2 probe conţin amestec de PEG cu Polisorbat 60. La analiza microscopică, mărimea medie a particulelor la probele obţinute aveau dimensiuni de 4 ori mai mici în comparaţie cu substanţa iniţială, cele mai omogene din punct de vedere morfologic fiind nanoparticulele din proba 3,5,6. Concluzii. Au fost obţinute şi studiate la microscop electronic nanoparticule de fenoxitiazolcloral. Au fost selectate 3 probe pentru cercetarea ulterioară al stabilităţii şi a disponibilităţii in vitro.en_US
dc.description.abstractIntroduction. The optimization of bioavailability of the new synthetized drugs is one of the biggest challenges in the rational design of the drugs. The insurance of an accepted solubility can be achieved by the production of the nanoparticles. Almost 80% of the scientific articles about the nanoparticles, show an increase in solubility of the nanoparticles rather than of the initial substance. Phenoxythiazolechloralum was synthetized at the Chemical Institute. It represents an antituberculosis substance with a high therapeutical potential, but it possesses a poor solubility. Thus, it is assumed that the change in the particles’ size by nano-ionization can contribute to the improvement of its solubility. The aim of the study. The attainment of the phenoxythiazolechloralum nanocrystals with the help of the modem technologies. Material and methods. The study and the analysis of the scientific literature about the obtainment of the nanoparticles. Nano-ionization by dry milling. OHAUS analytical balance, Pearl mill, Mikos microscope. Phenoxythiazolechloralum, PEG, Polysorbate 60. Results. It was selected the most relevant methods for the production of the nanocrystals, pearl milling and high pressure homogenization. There were obtained 6 samples of nanoparticles: 2 samples containing PEG; 2 samples containing Polysorbate 60 and other 2 samples containing a mixture of PEG and Polysorbate 60. The average size of the particles of the obtained samples was 4 times smaller in comparison with the initial substance under microscopic examination, and the nanoparticles from the samples 3,5,6 were the most homogeneous. Conclusions. It was obtained and studied under the electronic microscope the phenoxythiazolechloralum nanoparticles. Three samples were selected for the further stability and bioavailability in vitro researches.en_US
dc.publisherAsociația Farmaciștilor din Republica Moldovaen_US
dc.relation.ispartofRevista Farmaceutică a Moldovei: The First Congress of Pharmaceutical Students Association from Republic of Moldova dedicated to the Year Nicolae Testemitanu "Innovation and creativity in pharmaceutical practice and research”, May 4-7, 2017, Chisinau, Republic of Moldovaen_US
dc.subjectphenoxythiazolechloralumen_US
dc.subjectnanocrystalsen_US
dc.subjectpearl millen_US
dc.subjectsolubilityen_US
dc.titleObţinerea nanocristalelor de fenoxitiazolcloralen_US
dc.title.alternativeThe production of the phenoxythiazolechloralum nanocrystalsen_US
dc.typeArticleen_US
Appears in Collections:Revista Farmaceutică a Moldovei Nr. 1-2, 2017

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