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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/16645
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dc.contributor.authorBîlici, Ecaterina-
dc.contributor.authorUncu, Andrei-
dc.date.accessioned2021-04-12T13:14:55Z-
dc.date.available2021-04-12T13:14:55Z-
dc.date.issued2017-
dc.identifier.citationBÎLICI, Ecaterina, UNCU, Andrei. Identificarea prin reacţii chimice a propiltodiazolochinazolin-onei la etapa de preformulare a capsulelor operculate = The identification of propyltiodiazolochinazolin-one by chemical reactions at the preformulation stage of the operculate capsules. In: Revista Farmaceutică a Moldovei. 2017, nr. 1-2, p. 31. ISSN 1812-5077.en_US
dc.identifier.issn1812-5077-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/16645-
dc.descriptionUniversitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldovaen_US
dc.description.abstractIntroducere. Identificarea substanţelor medicamentoase prin reacţii chimice este o cerinţă indispensabilă în cercetarea farmaceutică. Acestea trebuie să fie cât mai specifice şi sensibile substanţei studiate, în rezultatul căreia obligatoriu necesită să se obţină un efect analitic. Propiltiodiazolochinazolin-ona (MF-1) este un derivat de 1,3,4-tiadiazol ce conţine în structura sa doi atomi de azot terţiari. Conform proprietăţilor fizice, fizico-chimice şi a structurii chimice, substanţa poate fi identificată cu ajutorul reactiviilor de precipitare a alcaloizilor. Scopul studiului. Este de a identifica substanţa activă la etapa de preformulare. Material şi metode. Substanţa activă propiltiodiazolochinazolin-ona şi excipienţi: lactoză monohidrat, lactoză anhidră, stearat de magneziu, celuloză microcristalină, polivinilpirolidonă. Solvent: cloroform. Reactivi de precipitare a alcaloizilor preparaţi în conformitate cu cerinţele Farmacopeei Europene: acid picric (I), reactivul Mayer (II), acidul fosfomolibdenic (III), acidul fosforovolframic (IV), ustensile de laborator. Rezultate. Au fost efectuate reacţii chimice de identificare cu reactivi de precipitare a alcaloizilor a patru formulări de capsule cu excipienţi diferiţi. Au fost obţinute extracţii cloroformice ale formulărilor şi soluţia standard cloroformică de MF-1. Toate soluţiile cloroformice analizate au manifestat efecte analitice similare: I -coloraţie galbenă, II - precipitat alb, III - precipitat oranj-cărămiziu, IV - coloraţie galbenă. Aceste rezultate ne indică faptul că excipienţii utilizaţi la elaborarea amestecurilor pentru încapsulare nu influenţează asupra efectului analitic al reacţiilor de identificare a substanţei active. Concluzii. Conform datelor obţinute în urma identificării substanţei cercetate prin reacţi chimice la etapa de preformulare, s-a stabilit că toate formulările dau rezultate pozitive cu reactivii de precipitarea a alcaloizilor.en_US
dc.description.abstractIntroduction. The identification of active substances by chemical reactions is an essential requirement in pharmaceutical research. The chemical reactions should be the most specific and the most sensitive one for the investigated substance and as a result it must obtain an analytical effect. Propylthiodiazolochinazolin-one (MF-1) is a derivative of 1,3,4-thiadiazol that contains in its structure two atoms of tertiary amine. The substance can be identified with the alkaloidal reagents due to its chemical structure, physical and physico-chemical properties. The aim of the study. Is to identify the active substance at the preformulation stage. Material and methods. The active substance: propylthiodiazolochinazolin-one and the excipients: lactose monohydrate, anhydrous lactose, magnesium stearate, polyvinylpyrrolidone, microcrystalline cellulose. The solvent: chloroform. Alkaloidal reagents were prepared in accordance with the requirements of the European Pharmacopoeia: picric acid (I), Mayer reagent (II), phosphomolybdic acid (III), phosphorowolphramic acid (IV). Laboratory equipment. Results. It was performed the chemical reactions with alkaloidals reagents of the four formulations of capsules with different excipients. It was obtained the chloroformic extractions of the formulations and chloroformic standard solution of MF-1. All analyzed chloroformic solutions showed similar analytical effects: I - yellow coloration, II - white precipitate, HI - orange-scarlet precipitate, IV - yellow coloration.The results denote that the excipients used in the preparation of mixtures for encapsulation have no influence on identifying the active substance. Conclusions. It was established that all the formulations have positive results with the alkaloidal reagents, according to the obtained data after identification of the investigated substance at the preformulation stage of the operculate capsules.en_US
dc.publisherAsociația Farmaciștilor din Republica Moldovaen_US
dc.relation.ispartofRevista Farmaceutică a Moldovei: The First Congress of Pharmaceutical Students Association from Republic of Moldova dedicated to the Year Nicolae Testemitanu "Innovation and creativity in pharmaceutical practice and research”, May 4-7, 2017, Chisinau, Republic of Moldovaen_US
dc.subject1,3,4-thiadiazolen_US
dc.subjectcapsulesen_US
dc.subjectalkaloidal reagentsen_US
dc.subjectpropylthiodiazolochinazolin-oneen_US
dc.titleIdentificarea prin reacţii chimice a propiltodiazolochinazolin-onei la etapa de preformulare a capsulelor operculateen_US
dc.title.alternativeThe identification of propyltiodiazolochinazolin-one by chemical reactions at the preformulation stage of the operculate capsulesen_US
dc.typeArticleen_US
Appears in Collections:Revista Farmaceutică a Moldovei Nr. 1-2, 2017

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