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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/17670
Title: Vaginal progesterone decreases preterm birth < 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the opptimum study
Authors: Romero, R.
Nicolaides, K. H.
Conde-Agudelo, A.
O’Brien, J. M.
Cetingoz, E.
Fonseca, E. DA
Creasy, G. W.
Hassan, S. S.
Keywords: cervical length;neonatal morbidity;neonatal mortality;prematurity;preterm delivery;progestins;progestogens;transvaginal ultrasound
Issue Date: 2017
Publisher: Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului
Citation: ROMERO, R., NICOLAIDES, K. H., CONDE-AGUDELO, A., et al. Vaginal progesterone decreases preterm birth < 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the opptimum study. In: Buletin de perinatologie. 2017, nr. 4(76), pp. 27-38. ISSN 1810-5289.
Abstract: Objective. To evaluate the efficacy of vaginal progesterone administration for preventing preterm birth and perinatal morbidity and mortality in asymptomatic women with a singleton gestation and a mid-trimester sonographic cervical length (CL) < 25 mm. Methods. This was an updated systematic review and meta-analysis of randomized controlled trials comparing the use of vaginal progesterone to placebo/no treatment in women with a singleton gestation and a mid-trimester sonographic CL < 25 mm. Electronic databases, from their inception to May 2016, bibliographies and conference proceedings were searched. The primary outcome measure was preterm birth < 34 weeks of gestation or fetal death. Two reviewers independently selected studies, assessed the risk of bias and extracted the data. Pooled relative risks (RRs) with 95% confidence intervals (CI) were calculated. Results. Five trials involving 974 women were included. A meta-analysis, including data from the OPPTIMUM study, showed that vaginal progesterone significantly decreased the risk of preterm birth < 34 weeks of gestation or fetal death compared to placebo (18.1% vs 27.5%; RR, 0.66 (95% CI, 0.52-0.83); P = 0.0005; five studies; 974 women). Meta-analyses of data from four trials (723 women) showed that vaginal progesterone administration was associated with a statistically significant reduction in the risk of preterm birth occurring at < 28 to < 36 gestational weeks (RRs from 0.51 to 0.79), respiratory distress syndrome (RR, 0.47 (95% CI, 0.27-0.81)), composite neonatal morbidity and mortality (RR, 0.59 (95% CI, 0.38-0.91)), birth weight < 1500g (RR, 0.52 (95% CI, 0.34-0.81)) and admission to the neonatal intensive care unit (RR, 0.67 (95% CI, 0.50-0.91)). There were no significant differences in neurodevelopmental outcomes at 2 years of age between the vaginal progesterone and placebo groups. Conclusion. This updated systematic review and meta-analysis reaffirms that vaginal progesterone reduces the risk of preterm birth and neonatal morbidity and mortality in women with a singleton gestation and a mid-trimester CL < 25 mm, without any deleterious effects on neurodevelopmental outcome. Clinicians should continue to perform universal transvaginal CL screening at 18-24 weeks of gestation in women with a singleton gestation and to offer vaginal progesterone to those with a CL < 25 mm. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
metadata.dc.relation.ispartof: Buletin de perinatologie
URI: https://ibn.idsi.md/sites/default/files/j_nr_file/Buletin%20de%20Perinatologie_4_2017.pdf
http://repository.usmf.md/handle/20.500.12710/17670
ISSN: 1810-5289
Appears in Collections:Buletin de Perinatologie Nr. 4(76) 2017



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