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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19353
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dc.contributor.authorPopa, Cristina-
dc.contributor.authorSuvorchina, Olga-
dc.contributor.authorVîslouh, Oxana-
dc.date.accessioned2021-12-10T09:27:35Z-
dc.date.available2021-12-10T09:27:35Z-
dc.date.issued2014-
dc.identifier.citationPOPA, Cristina, SUVORCHINA, Olga, VÎSLOUH, Oxana. The study of compatibility of econazole nitrate and betamethasone dipropionate. In: MedEspera: the 5th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2014, p. 245.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19353-
dc.descriptionDepartment of Pharmaceutical and Toxicological chemistry, State Medical and Pharmaceutical University “Nicolae Testemifanu”, Chisinau, Republic of Moldovaen_US
dc.description.abstractIntroduction: Econazole nitrate is an antifungal substance of the imidazole class that is successfully used in the treatment of different types of mycosis, especially those caused by agents as Aspergillus flumigatus and Candida albicans. According to WHO every fifth person is affected by a fungal disease. Mycoses are often associated with secondary infection followed by inflamation. that is why one of the possible drug combinations in the treatment of this disease is the combination between econazole nitrate and betamethasone dipropionate. Purpose and objectives: Studying the compatibility of econazole nitrate and betamethasone dipropionate using different modern methods and analysation of the results from different perspectives. Materials and methods: The research is based on the identification of econazole nitrate and betamehtasone using the Infrared Spectrophotometry and the determination of the content of each substance in the mixture using UV-VIS Spectrophotometry and the HPLC chromatography. Results: Infrared spectrums of econazole nitrate, betamethasone dipropionate and the mixture of econazole nitrate and betamethasone dipropionate (prepared from 1,0 g of each substance) show that there are few interactions between them. Infrared Spectrophotometry, as a modern method of analyse, is used only for identification of the substances, so it doesn't reveal any quantitative aspects. According to this, for testing forward the compatibility o f the analyzed substances there were recorded UV-VIS spectrums using different solvents such as C2H50H 96%, CH30H, HCi O.IM (according to European Pharmacopoeia). The recorded UV-VIS spectrums show that the substances by themselves correspond by quantitative aspects, but the mixture of them doesn't correspond. The compatibility of econazole nitrate and betamethasone dipropionate was also tested using HPLC chromatography. Chromatograms of econazole nitrate, betamethasone dipropionate taken on their own mobile phase show quantitative correspondence, but chromatograms of the mixture taken on the mobile phase of each substance doesn’t reveal any compatibility. Conclusion: The study of compatibility of econazole nitrate and betamethasone dipropionate, based on using different modern methods, revealed that the substances are incompatible.en_US
dc.language.isoenen_US
dc.publisherMinistry of Health of the Republic of Moldova, State Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Associationen_US
dc.relation.ispartofMedEspera: The 5th International Medical Congress for Students and Young Doctors, May 14-17, 2014, Chisinau, Republic of Moldovaen_US
dc.subjecteconazoleen_US
dc.subjectbetamethasoneen_US
dc.subjectcompatibilityen_US
dc.subjectspectrumsen_US
dc.subjectchromatogramsen_US
dc.titleThe study of compatibility of econazole nitrate and betamethasone dipropionateen_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2014

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