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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19943
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dc.contributor.authorIuresco, Tatiana-
dc.contributor.authorSuvorchina, Olga-
dc.contributor.authorTihon, Iurie-
dc.date.accessioned2022-02-03T11:46:18Z-
dc.date.available2022-02-03T11:46:18Z-
dc.date.issued2012-
dc.identifier.citationIURESCO, Tatiana, SUVORCHINA, Olga, TIHON, Iurie. Argumentation of the component of combined antibacterial ear drops. In: MedEspera: the 4th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2012, pp. 245-246.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19943-
dc.description.abstractIntroduction: Combined medicines have an important role. They provide the advantages of combination therapy, extending the range of therapeutic options, also exclude the necessity of extemporal preparation of prescription formulations. However, it should take into account that the therapy with combined drugs it must be known the full composition of drug and pharmacological properties of each component, even if the properties are well known. Materials and methods: For research it was used State Nomenclature of drugs from Republic of Moldova (01.04.2012); Nomenclature of drugs of Romania (01.01.2012); State Register of drugs of Russia (01.01.2012) ; Formulation of European Medical Agency (01.01.2012); Formulation of USA (FDA Drugs) (01.01.2012) ; Formulation of Canada (01.01.2012); Great Britain Formulation (01.02.2012); instructions for use of drugs; Standards of quality of analytical documents and therapeutic protocols in otorhinolaryngology (section “ear diseases”). Results: The last years in the world pharmaceutical market appeared an huge number of drugs, including ear drops. Many of them are analogues of known drugs with the same composition, but with a different brand name and various manufacturers. In Moldova the arsenal of remedies with topical and ear application is quite low and there is only one local producer-Depofarm Gmb., which produces a single name for ear drops. There were proposed to analyze the composition and pharmacological action of substances containing in the most common ear drop to develop the new combinations, to increase the efficiency of treatment. The most products (58.3%) are combinations of antimicrobials, corticosteroids, antiinflammatory, anesthetic and antiseptic medicines. Unfortunately, there are not registered medicines of vegetable origin. The study records observations in the ORL department of the Municipal Hospital E. Coţaga, Chisinau revealed a large number (%) of admissions with diagnosis of otitis, especially perforation. The main goal in patients treatment with inflammatory diseases of the outer and middle ear is a local antibacterial and antiinflammatory one. A group of drugs commonly used for these diseases are fluoroquinolones antibiotics. The most popular fluoroquinolone antibiotic is ciprofloxacin. It has a broad spectrum of activity and is active against gram-positive and gram-negative microorganisms, as well as Chlamydia. Because of this it was chosen ciprofloxacin as the main active substance in the development of combined ear drops. Also, in combined therapy of inflammatory diseases it is important for medicines to contain raw vegetable materials. It was selected the plant basil (Ocimum basilicum L). It is used in medicine for its antibacterial, antiibflamator, antiseptic, antispasmodic effects. Conclusions: In conclusion it is important to develop a new antibacterial composition for ear diseases, containing raw vegetable materials.en_US
dc.language.isoenen_US
dc.publisherState Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Association, Scientific Association of Students and Young Doctorsen_US
dc.relation.ispartofMedEspera: The 4th International Medical Congress for Students and Young Doctors, May 17-19, 2012, Chisinau, Republic of Moldovaen_US
dc.subjectear dropsen_US
dc.subjectcombinated drugsen_US
dc.subjectantibacterial medicinesen_US
dc.subjectciprofloxacinen_US
dc.subjectbasilen_US
dc.titleArgumentation of the component of combined antibacterial ear dropsen_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2012

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