USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/20328
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBobrov, Elena-
dc.contributor.authorVislouh, Oxana-
dc.contributor.authorSuvorchina, Olga-
dc.date.accessioned2022-03-09T09:18:59Z-
dc.date.available2022-03-09T09:18:59Z-
dc.date.issued2010-
dc.identifier.citationBOBROV, Elena, VISLOUH, Oxana, SUVORCHINA, Olga. Elaboration of principle extractive method from skin ointment containing Izohidrafural and Methyluracil. In: MedEspera: the 3rd Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2010, pp. 103-104.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/20328-
dc.description.abstractThe objective was to create a new pharmaceutical form for external use - the combined ointment with Izohidrafural and Methyluracil, which combines the antibacterial action of Izohidrafural and the regenerating action of Methyluracil and also to elaborate the method of extraction of active principles from the ointment. Materials and methods: Izohidrafuralum, Methyluracilum, the excipients: Vaselinum album, Alcoholum cetylstearylicum, Propylenglycolum, Glycerinum, Tween 80, PEG 400, Natrii laurylsulfas; the extragents: Dimethylformamidum, Natrii hydroxidum 0.1mol/l and the mixture of these two substances; spectrophotometer Agilent 8453 UVVIS. Results: The combined ointment with Izohidrafural and Methyluracil can be used in treating skin diseases, in surgery, obstetrics and gynecology, ophthalmology, proctology due to high efficiency and good way of application. It was studied the concentrations of 0.1% for Izohidrafural and 5% for Methyluracil which ensure a good availability and the maximum pharmacological effect. To create the optimal formulation of ointment, the active substances have been incorporated into various excipients, of different nature. So it was investigated four compositions containing emulsion-type ointment bases OAV and W/O. It was established the manufacturing technology flow of the ointment. To select the optimal composition that would allow an effective therapeutic action and minimal side effects, first of all it was elaborated the optimal extraction method and after that it was used the dosage of active substances from the extract by UV-VIS spectrometry methods. So, it was analyzed the extraction with solution of 0.1% sodium hydroxide, dimethylformamide and the mixture: solution of 0.1% sodium hydroxide and dimethylformamide (1:3). It was recorded the absorption spectra in the region 250nm-450nm in the case of extraction with solution of 0.1% sodium hydroxide, 250­ 400nm in the case of extraction with dimethylformamide and 250-450nm in case of extraction with the mixture. Conclusions: 1 .Izohidrafural and Methyluracil have been incorporated into different excipients. As a result, it was investigated four compositions containing emulsion-type ointment bases O/W and W/O; 2.1t was selected the optimal manufacturing technology for the compositions; 3.1t was elaborated the extraction with solution of 0.1% sodium hydroxide, dimethylformamide and the mixture of these two substances; 4.1t was concluded that the optimal extraction method is with dimethylformamide.en_US
dc.language.isoenen_US
dc.publisherNicolae Testemitanu State Medical and Pharmaceutical Universityen_US
dc.relation.ispartofMedEspera: The 3rd International Medical Congress for Students and Young Doctors, May 19-21, 2010, Chisinau, Republic of Moldovaen_US
dc.titleElaboration of principle extractive method from skin ointment containing Izohidrafural and Methyluracilen_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2010



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback