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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/21225
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dc.contributor.authorSchirliu, Marina-
dc.date.accessioned2022-06-17T09:39:06Z-
dc.date.available2022-06-17T09:39:06Z-
dc.date.issued2022-
dc.identifier.citationSCHIRLIU, Marina. Five diseases make a mixed connective tissue disease. In: MedEspera: the 9th International Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2022, p.175.en_US
dc.identifier.urihttps://medespera.asr.md/en/books?page=1-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/21225-
dc.description.abstractIntroduction. Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that has 5 other connective tissue diseases: systemic lupus erythematosus, systemic sclerosis, polymyositis, dermatomyositis and rheumatoid arthritis. A sixth - Sjögren's syndrome, is commonly associated with each of these diseases. Current clinical records often note that one autoimmune rheumatic disease seems to evolve into another over the course of several years and this occurs in approximately 25 percent of patients. Case presentation. We report a case of a female patient A, 43 y.o., she is complains started with the insidious onset manifested by inflammatory joint syndrome of bilateral radiocarpal, talocrural, synovitis of knee joints and decreased muscle strength, morning stiffness > 30 minutes with relief from exercise and movement, swelling of the proximal and distal metacarpophalangeal joints, skin hyperpigmentation on the trunk, heart palpitations, positive Shirmer test, weight loss 10 kg, severe fatigue by VAS - 82/100 mm. Discussion. Radiography features showed erosions and deforming like in rheumatoid arthritis. Echo showed moderate pulmonary hypertension, mitral and tricuspid valve regurgitation stage II. Serological examination showed (anti-CCP, ScL-70, dsDNA -negative, C3, C4- norma, rheumatoid factor, anti-RNP are positive. A diagnosis of MCTD was made, based on the criteria of Alarcón-Segovia and Villareal; patients met both clinical and serological criteria, with Anti-RNP values in high titers. Conclusion. MCTD is a well-defined entity using well-defined criteria. The complications of the disorder have already been described, most deaths from MCTD are due to heart failure caused by pulmonary arterial hypertension and ILD because it is important to note that both comorbidities worsen patient prognosis. The medications and dosage will depend on the severity of activity and damage disease.en_US
dc.language.isoenen_US
dc.publisherNicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova, Association of Medical Students and Residentsen_US
dc.relation.ispartofMedEspera: The 9th International Medical Congress for Students and Young Doctors, May 12-14, 2022, Chisinau, Republic of Moldovaen_US
dc.titleFive diseases make a mixed connective tissue diseaseen_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2022

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