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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/22235
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dc.contributor.authorCumpata, Veronica-
dc.contributor.authorSacara, Victoria-
dc.contributor.authorTurcanu, Adela-
dc.date.accessioned2022-11-09T07:59:10Z-
dc.date.available2022-11-09T07:59:10Z-
dc.date.issued2022-
dc.identifier.citationCUMPATA, Veronica, SACARA, Victoria, TURCANU, Adela. Exchangeable copper - a new diagnostic indicator for Wilson's disease: [poster]. In: Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie 2022: culegere de postere electronice. 2022, p. 86.en_US
dc.identifier.urihttps://conferinta.usmf.md/wp-content/uploads/culegere_de_postere_2022.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/22235-
dc.description.abstractIntroduction. Wilson”s disease (WD) biochemical markers continue to evolve. Classical tests have their own limits (tab.1), and they are often insufficient to diagnose or exclude WD. The free copper was proposed as a diagnostic test, but it was showed a large overlapping of this parameter between non-WD subjects and WD patients. New biomarkers are being investigated. Purpose. The paper aims to analyze the bibliographic data on the new tools for diagnostic in WD, like exchangeable copper (CuEXC). Material and methods. An advanced search was performed in the PubMed, and ScienceDirect databases, using the search English terms: ”Wilson's disease”, ”diagnostic test” and ”relative exchangeable copper”. Results. CuEXC is a new validated method for the direct determination of labile copper that can be correlated with the toxic fraction of copper and used to monitor treatment in Wilson patients. The relative exchangeable copper (REC) - the ratio of CuEXC/total serum copper is the best biomarker for the diagnosis of WD showing 100% sensitivity and 100% specificity. Studies confirm that a REC value >18.5% appears to be a highly discriminatory tool to differentiate WD between controls, presymptomatic patients, heterozygotes, and patients with non-Wilsonian liver disease, in cirrhosis and cholestasis, both in adults and in children. Family screening in asymptomatic subjects observed that REC determination significantly differentiated subjects non-WD from WD patients with a cutoff of 15%. Conclusions. CuEXC proved a helpful contribution in starting quickly the treatment without waiting for genetic testing results. Being a tool with high sensitivity and specificity, the determination of REC can be useful, reliable, rapid, and easy to set up to confirm or exclude WD in both adults and children, in carriers or asymptomatic patients.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldovaen_US
dc.relation.ispartofConferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 2022en_US
dc.subjectWilson's diseaseen_US
dc.subjectdiagnostic testen_US
dc.subjectexchangeable copperen_US
dc.titleExchangeable copper - a new diagnostic indicator for Wilson's diseaseen_US
dc.typeOtheren_US
Appears in Collections:Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie, 2022: Culegere de postere

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