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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/22525
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dc.contributor.authorTomacinschii, Cristina-
dc.contributor.authorȘciuca, Svetlana-
dc.date.accessioned2022-11-14T12:51:42Z-
dc.date.available2022-11-14T12:51:42Z-
dc.date.issued2022-
dc.identifier.citationTOMACINSCHII, Cristina, ȘCIUCA, Svetlana. Infecțiile sistemului bronhopulmonar la copii cu imunodeficiențe primare. In: Culegerea de lucrări a Conferinței Internaționale "Imunopedia": ed. 2, 9-10 septembrie/ Svetlana Șciuca, Alexis Cochino [et al]. Chişinău: s.n., 2022 (CEP Medicina), pp. 72-80. ISBN 978-9975-82-300-5.en_US
dc.identifier.isbn978-9975-82-300-5-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/22525-
dc.description.abstractPrimary immunodeficiencies (PIDs) are genetic diseases of the immune system, with quantitative and/or qualitative defects of one or more of its components, being affected: the development, function, and/or morphology of the immune system. Respiratory manifestations in IDP are represented by a varied spectrum, representing the most frequent cause of morbidity (63-88%), but also of mortality (30-65%). Timely diagnosis and appropriate therapy can improve or at least slow down the progression of these complications Aim: Considering the increased frequency of infections among patients with primary immunodeficiencies, it was proposed to evaluate respiratory infections and pathogens involved in pediatric primary immunodeficiencies. Methods: 14 children with primary immunodeficiencies (42.8% with primary immunodeficiencies due to antibody deficiency and 57.2% with combined primary immunodeficiencies) were included in the study. The diagnosis of PID was confirmed by the evaluation of serum IgA, IgM, IgG by the ELISA method in the immunology laboratory of IMC Chisinau, the determination of lymphocytes and lymphocyte subpopulations by lymphocyte immunophenotyping, genetic research. The frequency of infections was determined by analysis of laboratory charts, and oropharyngeal smear 73 and sputum bacteriology and subsequent culture were performed to identify the pathogens involved. Results: In the studied group, pneumonia was present in 49.2% of patients with combined immunodeficiency, in the case of patients with humoral link damage, pneumonia was more common among those with variable common immunodeficiency (84%), hyperIgM (81%) and disease Bruton (62%). In their etiology, following the culture of sputum and oropharyngeal secretions, the following were determined: St. Aureus 38.4% (95%CI 13.8-68.4%); Str beta haemolytic 46.1% (95% CI 19.2-74.8%); Cl. Pneumoniae 30.7% (95%CI 9-61.4%); Str. Pyogenes 53.8% (95%CI 25.1-80.7%); Candida white. 38.4% (95%CI 13.8-68.4%); P. aeruginosa 15.3% (95%CI 1.9-45.4%); H. Influenzae 30.7% (95%CI 9-61.4%); Moraxella cath. 23.8% (95%CI 5-53.8%); P. jirovecii 7.6% (95%CI 0.1-36%); Respiratory infections in immunodeficient patients are usually severe, persistent, caused by unusual, atypical, or opportunistic microorganisms, and recurrent compared to infections in non-IPD patients. Conclusion: Primary immunodeficiencies are predominantly rare diseases with clinical and immunological polymorphism. Severe IDPs in children evolve with pulmonary infections with polyresistant and opportunistic germs, which determine major risks of unfavorable developments. Early diagnosis, preventive measures, and immunoglobulin replacement treatments reduce the risks of acquiring infections with polyresistant germs and improve the prognosis and quality of life of patients.en_US
dc.language.isoroen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldovaen_US
dc.relation.ispartofConferința Internațională "Imunopedia": ediția 2, 9-10 septembrie 2022, Chișinăuen_US
dc.titleInfecțiile sistemului bronhopulmonar la copii cu imunodeficiențe primareen_US
dc.title.alternativeInfections of the bronchopulmonary system in children with primary immunodeficiencyen_US
dc.typeArticleen_US
Appears in Collections:Culegerea de lucrări a Conferinței Internaționale "Imunopedia": ediția 2, 9-10 septembrie 2022, Chișinău

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