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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/24153
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dc.contributor.authorBaltaga, Ruslan-
dc.contributor.authorPerciun, Andrei-
dc.contributor.authorBadan, Andrei-
dc.contributor.authorTurchin, Radu-
dc.contributor.authorCotelea, Valeria-
dc.date.accessioned2023-05-03T09:36:01Z-
dc.date.available2023-05-03T09:36:01Z-
dc.date.issued2023-
dc.identifier.citationBALTAGA, Ruslan, PERCIUN, Andrei, BADAN, Andrei, et al. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2023, vol. 10(1), pp. 82-89. ISSN 2345-1467. https://doi.org/10.52645/MJHS.2023.1.12en_US
dc.identifier.issn2345-1467-
dc.identifier.urihttps://cercetare.usmf.md/sites/default/files/inline-files/MJHS_10_1_2023.pdf-
dc.identifier.urihttps://doi.org/10.52645/MJHS.2023.1.12-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/24153-
dc.description.abstractIntroduction. A major role and, at the same time, a question mark, both for patients and doctors, is the possibility that drugs and anesthetic techniques influence cancer metastasis. Cancer is the leading cause of death worldwide. This trend will continue in the future. Most of the deaths of cancer patients are due to complications arising from metastases. The metastasis process of a tumor depends on its intrinsic properties and interaction with the host. The treatment of tumors by performing a surgical intervention, radical or palliative, has a significant impact. For these reasons, the rate of survival and migration of cancer cells in the perioperative period is studied quite insistently and complexly. Thus, surgical intervention and anesthetic support in cancer patients becomes of great importance, because it represents the vulnerable link, both from the point of view of the operation itself, as well as the possibility that drugs, anesthetic techniques may or may not influence tumor metastasis. Material and methods. Primary scientific studies published from 1996 to 2021 dedicated to loco-regional anesthesia and its influence on the perioperative period and on cancer metastasis were studied. To achieve the proposed goal, scientific sources PubMed, Medscape, SCOPUS, MEDLINE were researched. Keywords used for searching: loco-regional anesthesia, fascia plane anesthesia, metastasis. More than 80 reference sources were identified, 67 were selected for analysis. Results and discussions. The surgical procedure, itself, performed for curative purposes, also known as tumor resection – is a risk factor for metastasis by creating an environment with high potential for tumor cell survival. This stimulates tumor growth and angiogenesis, can remodel lymphatic pathways, allowing metastasis of tumor cells. Hemotransfusion is associated with increased risk of metastasis. Regional anesthesia could reduce cancer recurrence through several mechanisms. Conclusions. Regional anesthesia could reduce cancer recurrence by reducing the need for opioids or inhaled anesthetics, or by reducing the stress response during surgery. There is scientific in vitro evidence of a protective effect of systemic lidocaine on recurrent cancer, although relevant clinical data are limited.en_US
dc.language.isoenen_US
dc.publisherInstituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldovaen_US
dc.relation.ispartofRevista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciencesen_US
dc.subjectcancer recurrenceen_US
dc.subjectgeneral anesthesiaen_US
dc.subjectregional anesthesiaen_US
dc.subjectstress responseen_US
dc.subjectopioid analgesicsen_US
dc.subjectangiogenesis inducing agentsen_US
dc.subjectmorphineen_US
dc.subjectonco-anesthesiaen_US
dc.subject.ddcUDC: 616-006.6-009.624en_US
dc.titleLoco-regional analgesia in oncology. Influence on cancer recurrence rate. Literature review.en_US
dc.typeArticleen_US
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2023 nr. 1(10)



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