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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/24179
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dc.contributor.authorPantea, Valeriana-
dc.contributor.authorPopa, Veaceslav-
dc.contributor.authorTagadiuc, Olga-
dc.contributor.authorAndronache, Lilia-
dc.contributor.authorGudumac, Valentin-
dc.date.accessioned2023-05-04T10:02:55Z-
dc.date.available2023-05-04T10:02:55Z-
dc.date.issued2022-
dc.identifier.citationPANTEA, Valeriana, POPA, Veaceslav, TAGADIUC, Olga, et al. Changes of oxidative stress indices and antioxidant system in the liver tissue on the administration of some coordination compound of copper, derivatives of thiosemicarbazide. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2022, vol. 29(3), pp. 7-12. ISSN 2345-1467.en_US
dc.identifier.issn2345-1467-
dc.identifier.urihttps://cercetare.usmf.md/sites/default/files/inline-files/29_3_2022.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/24179-
dc.description.abstractAbstract. Introduction. Identification, study and testing of new remedies for treatment approaches of diseases, resulting from imbalance between oxidants and antioxidants in favor of oxidants, with potentially destructive potential and pathogenesis in liver disorders is of particular interest due to the increase in incidence and severity of these pathologies. Material and methods. The action of novel local copper coordination compounds, thiosemicarbazide derivatives - CMD-4, CMJ-33 and CMT-67, was evaluated in experiments on white rats after subcutaneous administration in two different doses (0.1 and 1.0 µM/kg) 3 times a week for 30 days. The main indices of oxidative stress were evaluated: the level of malonic dialdehyde (MDA), nitric oxide derivatives (NO), S-nitrosothiols, advanced glycation end products (AGEs), advanced oxidation protein products (AOPP) and ischemia-modified proteins (IMP), and antioxidant system: - superoxidismutase (SOD) and catalase activity (CAT), the level of histidine (His) and total antioxidant activity (TAA) in liver tissue of white rats. Results. The administration of CC resulted in the reduction of oxidative stress indices - MDA, AGEs and S-nitrosothiols, which denotes the antioxidant effect of the studied compounds. The level of NO and AOPP derivatives does not change substantially. When administering CMD-4 (1 µM/kg), SOD activity and catalase function decreased markedly. Changes in the content of His and TAA have been shown to be inconclusive, maintaining within the limits of the values recorded in the control group. Conclusions. The elucidation of the modifications of the free radicals processes in liver tissues, which are the basis of the CC action, broadens the theoretical knowledge about the biological properties of a number of chemical compounds; as well provide new possibilities to explore perspective objects in order to obtain new efficient drug preparations.en_US
dc.language.isoenen_US
dc.publisherInstituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldovaen_US
dc.relation.ispartofRevista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciencesen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant systemen_US
dc.subjectliver tissueen_US
dc.subjectcoordination compounds of copperen_US
dc.subject.ddcUDC: 616.36-092.9:577.121.7+546.56en_US
dc.titleChanges of oxidative stress indices and antioxidant system in the liver tissue on the administration of some coordination compound of copper, derivatives of thiosemicarbazideen_US
dc.typeArticleen_US
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2022 nr. 3(29)



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