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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/24285
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dc.contributor.authorMihalcean, Luminita-
dc.contributor.authorRotaru, Victoria-
dc.contributor.authorTitica, Elena-
dc.date.accessioned2023-05-12T11:43:25Z-
dc.date.available2023-05-12T11:43:25Z-
dc.date.issued2022-
dc.identifier.citationMIHALCEAN, Luminita, ROTARU, Victoria, TITICA, Elena. Pathogenetic correlation of severe sepsis and multiple organ dysfunction syndrome provoked by multiple infections in perinatal period of women. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2022, vol. 30(4), pp. 70-75. ISSN 2345-1467. https://doi.org/10.52645/MJHS.2022.4.12en_US
dc.identifier.issn2345-1467-
dc.identifier.urihttps://cercetare.usmf.md/sites/default/files/inline-files/REVISTA%20DE%20%C8%98TIIN%C8%9AE%20ALE%20S%C4%82N%C4%82T%C4%82%C8%9AII%20DIN%20MOLDOVA%20NR.%204%2C%202022_0.pdf-
dc.identifier.urihttps://doi.org/10.52645/MJHS.2022.4.12-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/24285-
dc.description.abstractAbstract. Introduction. Despite significant advances in diagnosis, medical management and antimicrobial therapy, sepsis in the puerperium remains an important cause of maternal morbidity and mortality. The abnormalities associated with the clinical syndrome of sepsis result from a nonspecific innate inflammatory response. This is due to the fact that sepsis represents a systemic inflammatory response syndrome (SIRS) to infection or injury; therefore, it can rapidly progress to septic shock and death despite aggressive treatment. Severe sepsis with MODS has a mortality rate of 20– 40%, rising to around 60% if septicemic shock develops. Symptoms of sepsis may be less distinctive than in the non-pregnant population and are not necessarily present in all cases; therefore, a high index of suspicion is necessary. The major pathogens causing sepsis in the puerperium are: group A streptococcus (GAS), also known as Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, Streptococcus pneumonia, methicillin-resistant S. aureus (MRSA), Clostridium septicum, Morganella morganii and antibiotic-resistant Stenotrophomonas Moltrophilia. Multiple risk factors for maternal sepsis have been identified: obesity, impaired glucose tolerance/diabetes, impaired immunity/immunosuppressant medication, anemia, vaginal discharge, history of pelvic infection, amniocentesis and other invasive procedures, cervical cerclage, prolonged spontaneous rupture of membranes, caesarean section, wound hematomas, retained products of conception, GAS infection, vaginal trauma. Material and methods. Presentation of case report using the following key-words: „infection”, „systemic inflammatory response syndrome (SIRS)”, „severe sepsis”, „septic shock”, „multiorgan dysfunction syndrome (MODS)”. Results. We present a case of perinatal infections complicated with MODS. Conclusions. The presence of pelvic hematomas triggers the sepsis caused by multiple infections in perinatal period and can significantly increase the morbidity related to bleeding, infection, surgery and blood product transfusion. The clinical situation may worsen in the presence of pre-existing pathological conditions before pregnancy.en_US
dc.language.isoenen_US
dc.publisherInstituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldovaen_US
dc.relation.ispartofRevista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciencesen_US
dc.subjectperinatal infectionsen_US
dc.subjectpelvic hematomasen_US
dc.subjectsystemic inflammatory response syndromeen_US
dc.subjectseptic shocken_US
dc.subjectmultiorgan dysfunction syndromeen_US
dc.subject.ddcUDC: 618.3/.7-002-022en_US
dc.titlePathogenetic correlation of severe sepsis and multiple organ dysfunction syndrome provoked by multiple infections in perinatal period of womenen_US
dc.typeArticleen_US
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2022 nr. 4(30)



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