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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/25052
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dc.contributor.authorStreltov, Liuba-
dc.contributor.authorGudumac, V.-
dc.contributor.authorRojnoveanu, Gh.-
dc.date.accessioned2023-06-20T13:08:34Z-
dc.date.available2023-06-20T13:08:34Z-
dc.date.issued2022-
dc.identifier.citationSTRELTOV, Liuba, GUDUMAC, V., ROJNOVEANU, Gh. The effect of bile decompression on pro- and antioxidant markers in the complications of gallstones associated with cholestatic jaundice. In: The medical-surgical journal = Revista medico-chirurgicală. 2022, nr. 126(3), pp. 378-387. doi: 10.22551/MSJ.2022.03.10en_US
dc.identifier.issn2286-2560-
dc.identifier.issn0048-7848-
dc.identifier.uridoi: 10.22551/MSJ.2022.03.10-
dc.identifier.urihttps://www.revmedchir.ro/index.php/revmedchir/article/view/2620/1845-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/25052-
dc.description.abstractArgumentation of optimal terms for a staged surgical approach in the benign complications of gallstones associated with cholestatic jaundice by assessing the effect of biliary decompression on pro-and antioxidant markers. Material and methods: Prospective study, selected 105 patients with complicated gallstones and associated cholestatic jaundice, divided into three homogeneous subgroups, dependent on evolutionary com-plication. Control group -35 patients with uncomplicated gallstones. All patients in the study group followed the staged treatment protocol in obstructive jaundice, with the primary prerogative -internal biliary decompression by endoscopic papillosphincterotomy. Pro-and antioxidant markers were assessed at hospitalization, on the 1st and 4th day after decompression. Results: Malonic dialdehyde at hospitalization marked in all subgroups with statistically significant results compared to the control group: I -12.11±0.64 mol/l [p<0.001 (t=10.7)], II -11.12±0.53mol/l [p<0.001 (t=10.9)]; III -13.16±0.44 mol/l [p<0.001 (t=16.5)]. The activity of the antioxidant system evaluated by superoxide dismutase values [p<0.001(t=6.4); (t=4.1); (t=5.7)] and catalase [p<0.001(t=6.7); (t=5.6); (t=7.6)] shows a decrease in all sub-groups compared to the control group. On the 1st day after drainage, malonic dialdehyde values did not show statistical significance compared to the before decompression state [I -p>0.05 (t=0.11); II -p>0.05 (t=0.91)]. An obvious reduction of its activity was found on the 4th after decompression day [I -p<0.001 (t=5.15; II -p<0.01 (t=2.6); III -p<0.001 (t =3.99)]. The return of the antioxidant systemin all subgroups to values relatively similar to the control group: superoxide dismutase [I -p<0.05 (t=2.21); II -p<0.05 (t=0.0008); III -p<0.05 (t=0.33)] and catalase [I -p<0.05 (t=2.39); II -p<0.05 (t=3.52); III -p<0.01 (t=2.87)] was found more than 4 days after decompression. Conclusions: The study demonstrated the positive influence of biliary decompression in the complications of gallstones associated with cholestatic jaundice for the reduction of a massive lipid oxidation and the creation of conditions for increasing the antioxidant capacity with the restoration of the body's biological balance, which is more pronounced 4-5 days after decompression, serving as criterion for the possibility of definitive resolution of gallstones in these terms.en_US
dc.language.isoenen_US
dc.publisherSociety of Physicians and Naturalistsen_US
dc.relation.ispartofThe medical-surgical journal = Revista medico-chirurgicalăen_US
dc.subjectcomplications of gallstonesen_US
dc.subjectcholestatic jaundiceen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant systemen_US
dc.titleThe effect of bile decompression on pro- and antioxidant markers in the complications of gallstones associated with cholestatic jaundiceen_US
dc.typeArticleen_US
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