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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/25082
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dc.contributor.authorTimercan, Tatiana
dc.date.accessioned2023-06-26T12:55:40Z
dc.date.available2023-06-26T12:55:40Z
dc.date.issued2023
dc.identifier.citationTIMERCAN, Tatiana. Meldonium – a new challenging subject in the performance sport. In: One Health & Risk Management. 2023, ed. spec.:„Tendințe actuale și provocări în medicina preventivă”, 8-9 iunie 2023: mater. conf. naț. cu particip. internațională. p. 42. ISSN 2587-3458.en_US
dc.identifier.issn2587-3458
dc.identifier.issn2587-3466
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/25082
dc.identifier.urihttps://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/issue/view/26/41
dc.description.abstractIntroduction. Nowadays sports have become a business that breaks any rules of Olympic ethics in order to win. The Doping phenomenon with artificial increase of athlete’s performance opposes the principle of fair and equitable competition. Abusive use of performance-enhancing drugs, such as meldonium, is widespread. World Anti-Doping Agency (WADA) Monitoring Program 2015 reported that about 25% of doping tests were positive for meldonium, they are the basis for the inclusion, since January 1, 2016, of meldonium in WADA International Standard Prohibited List as a metabolic modulator prohibited in- and out-of-competition. The COVID-19 pandemic due to the high risk of cardiovascular comorbidities has fostered an increase in Therapeutic Use Exemption (TUE) requests for the use of meldonium as cardio protector, posting a challenge to sports medicine. Aim. Highlight the bioethical and medical aspects of TUE requests for the use of meldonium in post-COVID recovery period by athletes. Material and methods. By applying mixed research methods within the State Program project “The phenomenon of doping in young athletes in the bioethicalmedical approach” the prevalence of TUE requests for the use of meldonium as a prophylactic medication for ischemic cardiac problems in athletes with COVID-19 infection was studied. The data from official reports published on the website of National Anti-Doping Agency (NADA) and Therapeutic Use Exemption Committee (TUEC) of Republic of Moldova was analyzed in order to define the realities of meldonium use in sports. Results. Meldonium is an anti-ischemic medicine that is not used (no Food and Drug Administration approvement) in the United States and most of West-Europe, but easily available without any medical prescription (as Mildronate, Grindex) in Russia, Ukraine, Belarus, Moldova and other Eastern European countries. The medicine is not included in any Clinical Protocol or Guide, but because it is registered at the State Agency of Medicines of Republic of Moldova, it can be prescribed at the doctor's decision to any patient with cardiac or cerebrovascular (acute or chronic) issues. According to the manufacturer description, meldonium restores the oxygen balance/supply in ischemic tissues and increases the endurance performance. In 2016, WADA included meldonium as a non-specified substance (metabolic modulator similar to AMPK) in class S4 – Hormone and Metabolic Modulators from WADA Prohibited List. Due to high rate of cardiac comorbidities caused by COVID-19 pandemic, and described metabolic, adaptogenic, antianginal, cardioprotective and antihypoxic effects of meldonium, recently was noticed an increase of meldonium use for cardio protection in patients with SARSCoV-19 infection. Conclusions. It was established that meldonium has high adaptogenic potential in physical and mental overloads, improving physical stamina and performance. The use of meldonium has become a challenging issue for sports medicine and WADA, has been constantly monitoring the data on the use of meldonium, as well as the number of TUEs or potential TUEs in different regions of the world, because nowadays the line between medicine and doping is very thin.en_US
dc.language.isoenen_US
dc.publisherAsociația de Biosiguranță și Biosecuritate din Republica Moldovaen_US
dc.relation.ispartofOne Health & Risk Management: Conferința națională cu participare internațională „Tendințe actuale și provocări în medicina preventivă” organizată în cadrul celei de-a XXXVII-a ediție a Săptămânii Medicale Balcanice „Perspective ale Medicinei Balcanice în era post COVID-19”, 8-9 iunie 202en_US
dc.subjectmeldoniumen_US
dc.subjectCOVIDen_US
dc.subjectWADAen_US
dc.subjectProhibited Listen_US
dc.subjectdopingen_US
dc.titleMeldonium – a new challenging subject in the performance sporten_US
dc.typeArticleen_US
Appears in Collections:One Health & Risk Management iunie 2023, Ediție specială

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