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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/2560
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dc.contributor.authorLupaşco, Iulianna
dc.date.accessioned2019-06-24T20:25:49Z-
dc.date.available2019-06-24T20:25:49Z-
dc.date.issued2011
dc.identifier.issn1857-0011
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/2560-
dc.descriptionUSMF „Nicolae Testemiţanu”en_US
dc.description.abstractPrin metode clinice şi de laborator au fost investigaţi 127 de pacienţi cu hepatită cronică virală C, cu determinarea stării funcţionale a glandei tiroide. Lot-martor a inclus 30 de persoane sănătoase. Faza infecţiei virale a fost apreciată prin testarea încărcăturii virale în sânge (PCR). Disfuncţia tiroidiană s-a depistat la 41.73% din pacienţi, inclusiv hiperfuncţia – la 22.83% şi hipotireoidia – la 18.90%. Anticorpi faţă de tireoperoxidază (TPO) au fost decelaţi în 40.15% cazuri, faţă de tireoglobulină – în 18.89%. A fost stabilită infl uenţa fazei infecţiei virale (replicare) asupra creşterii nivelului T3 şi T4, detectare mai frecventă a anticorpilor antitireoperoxidază. A fost depistată dependenţa dintre activitatea procesului hepatic şi funcţia glandei tiroide. Summary It was done a comprehensive clinical-laboratory examination of 127 patients with chronic hepatitis HCV with a detailed assessment of functional state of thyroid gland. 30 healthy people served as a control group. To characterize the viral infection phase we determined the concentration of virus in blood (PCR), a set of liver enzymes. Thyroid dysfunction was found in 41.73%, including its hyperfunction – 22.83%, and hypothyroidism in 18.90%. Presence of antibodies to thyroid peroxidase (TPO) was detected in 40.15% and to thyroglobulin in 18.89%. The levels of T3 and T4 in HCV replication phase where higher in comparison to latent phase and more often appeared antibodies to TPO. It was established the dependence of the liver process activity and the functional state of thyroid gland. Резюме Проведено комплексное клинико-лабораторное обследование 127 больных с хроническим HCV гепатитом с оценкой функционального состояния щитовидной железы. Контролем послужили 30 здоровых лиц. Для характеристики фазы вирусной инфекции и состояния печени определяли концентрацию вируса в крови (метод ПЦР) и комплекс печеночных проб. Дисфункция щитовидной железы выявлена в 41,73% случаев, в том числе гиперфункция – 22,83% и гипофункция – 18,90%. Наличие антител к тиреопероксидазе (ТПО) обнаружено в 40,15% и к тиреоглобулину – в 18,89% случаев, что свидетельствует о наличии аутоиммунных изменений в щитовидной железе. В фазе репликации HCV уровень Т3, Т4 выше, чем в латентном периоде и чаще выявляются антитела к ТПО. Установлена за- висимость активности печеночного процесса от функ- ционального состояния щитовидной железы.en_US
dc.language.isoroen_US
dc.publisherBuletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicaleen_US
dc.subject.meshHepatitis C, Chronicen_US
dc.subject.meshHepatitis, Viral, Humanen_US
dc.subject.meshThyroid Diseasesen_US
dc.subject.meshThyroid Hormonesen_US
dc.titleHepatita cronică virală C şi starea funcţională a glandei tiroideen_US
dc.typeArticleen_US
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