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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/25896
Title: Myasthenia gravis - acetylcholine receptors autoantibodies positive (AchR+ MG) subtypes and their clinical manifestations
Authors: Molla, Wael
Keywords: Myasthenia gravis;acetylcholine receptors;early-onset MG;late-onset MG
Issue Date: 2023
Publisher: Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova
Citation: MOLLA, Wael. Myasthenia gravis - acetylcholine receptors autoantibodies positive (AchR+ MG) subtypes and their clinical manifestations. In: Revista de Ştiinţe ale Sănătăţii din Moldova = Moldovan Journal of Health Sciences. 2023, vol. 10(3), anexa 1, p. 450. ISSN 2345-1467.
Abstract: Background. Myasthenia gravis is an autoimmune disease that affects the neuromuscular junction, resulting in disrupted transmission. B cells Autoantibodies that target acetylcholine receptors and components like muscle-specific tyrosine kinase, damage it and causing destruction and internalization of AChR. Objective of the study. The goal of this work is to discuss and research AChR+ MG (more common than AChR- MG), by focusing on the clinical and immunological aspects of MG and its subgroups based on their characterization of antigenic targets. Materials and methods: the research is focused on a descriptive and narrative literature reviews about AChR+ MG subtypes based on online resources like PubMed, MGFA official website, MDPI. Results. 1. Ocular MG: Most MG patients with initial ocular symptoms progress to generalized forms within two years, with symptoms as ptosis and diplopia. 2. AChR-MG has early-onset and late-onset subtypes. EOMG occurs before 50 years, often with thymic hyperplasia and positive response to thymectomy. LOMG occurs after 50 years, has no gender predilection, lower thymic hyperplasia prevalence, and a worse response to thymectomy. 3. Thymoma-associated MG: Around 50% of thymoma patients develop AChR-positive MG, with severe muscle weakness, especially in oropharyngeal muscles. Thymoma-MG can occur at any age, usually diagnosed between 40 and 60 years. Thymectomy has varying effectiveness. Conclusions. A unified clinical picture of various MG phenotypes requires a more in-depth study of immunochemical and neurophysiological aspects, which in turn makes it possible to select a more adequate treatment in each of the cases.
metadata.dc.relation.ispartof: Revista de Științe ale Sănătății din Moldova: Moldovan Journal of Health Sciences: Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 18-20 octombrie 2023, Chișinău, Republica Moldova
URI: https://conferinta.usmf.md/wp-content/uploads/Culegerea-Rezumate-MJHS_10_3_2023_anexa1.pdf
http://repository.usmf.md/handle/20.500.12710/25896
ISSN: 2345-1467
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2023 nr. 3(10) Anexa 1

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