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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/2725
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dc.contributor.authorVisternicean, Elena
dc.date.accessioned2019-06-24T21:45:14Z
dc.date.available2019-06-24T21:45:14Z
dc.date.issued2017
dc.identifier.citationVISTERNICEAN, Elena. Homocysteine and recurrent miscarriage. In: The Moldovan Medical Journal. 2017, vol. 60, no. 1, pp. 15-19. ISSN 2537-6373. DOI: 10.5281/zenodo.1050325en_US
dc.identifier.issn2537-6373
dc.identifier.issn2537-6381
dc.identifier.otherDOI: 10.5281/zenodo.1050325
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2017/02/MMJ-60-1-DOI-UDC.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/2725
dc.identifier.urihttps://doi.org/10.5281/zenodo.1050325
dc.descriptionDepartment of Obstetrics and Gynecology No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldovaen_US
dc.description.abstractBackground: It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine. Development mechanisms of vascular complications of hyperhomocysteinemia are currently being intensively studied. Hyperhomocysteinemia affects a number of mechanisms involved in thrombogenesis including coagulation cascade, vessel-thrombocytic section, oxidation-reduction reactions, endothelium, and vascular smooth muscle cells and is associated with an increased risk of adverse outcomes in pregnancy. Materials and methods: The study included 50 women who had experienced the loss of at least two consecutive pregnancies. The level of the total serum homocysteine was measured via the chemiluminescent method. Results: We found that plasma homocysteine concentration < 10 μmol/l was found in 16 patients (32,0%, 95% CI 19,07 – 44,93), 9 patients (18.0%, 95% CI 7,36 – 28,64) had a fasting plasma homocysteine between 10 μmol/l to 12 μmol/l and 25 patients (50.0%, 95%CI 36,15 – 63,85) had significantly high total serum homocysteine values. Among them, 23 patients (46.0%, 95%CI 32,19 – 59,81) had the concentration between 12 – 30 μmol/l and 2 patients (4,0%, 95%CI -1,43 – 9,43) had the concentration > 30μmol/l. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception. In the current study, 40 women (80.0%, 95% CI 68,92 – 91,08) have become pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy. Conclusions: The prevalence of hyperhomocysteinemia was more in unexplained primary early recurrent miscarriages. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception and 40 women (80.0%, 95% CI 68,92 – 91,08) became pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journal
dc.subjecthomocysteineen_US
dc.subjectspontaneous abortionen_US
dc.subjectrecurrent abortionen_US
dc.subjectvitamin B supplementationen_US
dc.subject.meshHomocysteine--blooden_US
dc.subject.meshAbortion, Habitualen_US
dc.subject.meshVitamin B Complex--therapeutic useen_US
dc.titleHomocysteine and recurrent miscarriageen_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal, Vol. 60, No 1, February 2017

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