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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/3068
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dc.contributor.authorКасьян, Игорь
dc.contributor.authorКасьян, Анна
dc.date.accessioned2019-06-25T00:12:35Z-
dc.date.available2019-06-25T00:12:35Z-
dc.date.issued2005
dc.identifier.issn1812-5077
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/3068-
dc.descriptionНациональный Институт Фармацииen_US
dc.description.abstractThe purpose of the given work was optimisation of the HPLC method for Glibenclamide determination in blood plasma and its adaptation for the chromatograph Jasco LC-1500 series. The desirable results were reached at usage of the chromatographic column Uptisphere 5 ODB, 3x150 mm, mixture acetonitrile - 0.01M H3PO4 (50:50) as a mobile phase and samples deproteinisated by copper sulphate and acetonitrile. The method is distinguished by the reduced expenditures of time, reagents and biostuff, also is applicable for carrying out of therapeutic monitoring of drug. Scopul lucrării date vizează optimizarea metodei HPLC de determinare a glibenclamidului în plasma sanguină şi adaptarea ei pentru cromatograful din seria “Jasco LC- 1500”. Rezultate satisfăcătoare au fost obţinute utilizând coloana cromatografică Uptisphere 5 ODB, 3x150 mm, eluarea în amestec acetonitril - O.OîM H3PO4 (50:50) în calitate de fază mobilă şi prepararea probelor prin metoda de deproteinizare cu sulfat de cupru şi acetonitril. Metoda se deosebeşte prin reducerea timpului, reactivelor şi materialului biologic şi poate fi utilizată la efectuarea monitoring -ului terapeutic medicamentos. Глибенкламид является оральным противодиабетическим средством из группы производных сульфонилмочевины II поколения. Зарекомендовал себя в качестве препарата выбора для лечения инсулинонезависимых форм сахарного диабета при сохранении продукции эндогенного инсулина. Препарат назначают в течение длительного времени. В то же время дозы необходимо подбирать индивидуально в зависимости от степени гипергликемии и индивидуальных особенностей фармакокинетики, что делает актуальной задачу проведения терапевтического лекарственного мониторинга.en_US
dc.language.isoruen_US
dc.publisherRevista Farmaceutică a Moldoveien_US
dc.subjectGlibenclamideen_US
dc.subjectHPLCen_US
dc.subjectOptimisationen_US
dc.subjectTherapeutic Drug Monitoringen_US
dc.subject.meshGlyburide - analysisen_US
dc.subject.meshPlasmaen_US
dc.subject.meshChromatography, Liquiden_US
dc.titleАдаптация и оптимизация метода определения Глибенкламида в плазме кровиen_US
dc.title.alternativeAdaptation and optimisation of the method for Glibenclamide determination in the blood plasmaen_US
dc.typeArticleen_US
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