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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/3072
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dc.contributor.authorCasian, Ana
dc.contributor.authorCasian, Igor
dc.contributor.authorValica, Vladimir
dc.date.accessioned2019-06-25T00:12:36Z-
dc.date.available2019-06-25T00:12:36Z-
dc.date.issued2005
dc.identifier.issn1812-5077
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/3072-
dc.descriptionInstitutul Naţional de Farmacie, MS RMen_US
dc.description.abstractRezumat In lucrare este prezentată evaluarea comparativă a eficienţei metodelor cu cheltuieli reduse de preparare a probelor de plasmă sau ser sanguin pentru investigarea ulterioară prin metoda HPLC cu fază inversă, bazate pe deproteinizarea cu diverşi precipitând şi extracţia omogenă. S-a determinat domeniul posibil de utilizare al fiecărei metode în funcţie de proprietăţile substanţelor analizate. Sunt făcute recomandări privind selectarea unei metode optime de preparare a probelor la elaborarea noilor metode de dozare a substanţelor medicamentoase în material biologic. Summary. The comparative evaluation of low-cost methods of biological samples preparation in pharmacokinetic researches. In paper the comparative estimation of some low-cost methods of sample preparation of blood plasma and serum to its ulterior research by the reversed-phase HPLC is given, based on depro- teinization by the various précipitants and single-phase extraction. The limits of possible usage of each method in dependence on properties of analytical substances have been determined. The guidelines for a choice of an optimum method of biological samples preparation at new analytical methods development for the active substances determination are given.en_US
dc.language.isoroen_US
dc.publisherRevista Farmaceutică a Moldoveien_US
dc.subjectHPLCen_US
dc.subject.meshPharmacokineticsen_US
dc.subject.meshChromatography, Liquiden_US
dc.subject.meshPlasmaen_US
dc.titleAprecierea comparativă a unor metode de preparare a probelor biologice pentru analiza HPLCen_US
dc.typeArticleen_US
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