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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/3971
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dc.contributor.authorTagadiuc, Olga
dc.contributor.authorGudumac, Valentin
dc.contributor.authorRîvneac, Victor
dc.contributor.authorAndronache, Lilia
dc.date.accessioned2019-06-25T11:34:56Z
dc.date.available2019-06-25T11:34:56Z
dc.date.issued2010
dc.identifier.citationTAGADIUC, Olga, GUDUMAC, Valentin, RÎVNEAC, Victor, ANDRONACHE, Lilia. Influenţa compuşilor coordinativi ai cuprului asupra activităţii proteazelor lizozomale hepatice în intoxicaţia cu propilenglicol. In: Anale Științifice ale USMF “Nicolae Testemiţanu”. Ed. a 11-a. Chișinău: CEP Medicina, 2010, vol. 1: Probleme medico-biologice si farmaceutice, pp. 261-266.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/3971
dc.descriptionLaborator biochimie USMF “N.Testemiţanu”en_US
dc.description.abstractWe studied the influence of copper coordinative compounds CMT-28 and CMT-67 and their combination with cyanobacterial remedy BioR on hepatic lysosomal proteases activity in intoxication with propylene glycol (PG). It was established that PG enhance statistically conclusive the activity of cathepsines D, G, L, H, B and leucinaminopeptidase in rat liver. All studied remedies in low doses (1 g/kg) reduced statistically reliable leucineaminopeptidase activity, CMT-28 and CMT-67+BioR influenced cathepsin H activity and CMT-67+BioR - cathepsin L activity. In high doses (10 mg/kg) statistically conclusive was reduced only the activity of cathepsin G by CMT-67, CMT-67+BioR, CMT-28+BioR and cathepsin H activity by CMT-28 + BioR. S-a studiat influenţa compuşilor coordinative ai cuprului CMT-28 şi CMT-67, precum şi a combinaţiilor lor cu remediul cianobacterian BioR asupra activităţii proteazelor lizozomale hepatice în intoxicaţia cu propilenglicol (PG). S-a stabilit că PG amplifică statistic concludent activitatea catepsinelor D, G, L, H, B şi a leucinaminopeptidazei în ficatul şobolanilor. În doze mici (1 mg/kg) toate preparatele studiate diminuează statistic veridic activitatea leucinamino-peptidazei, CMT-28 şi CMT-67 + BioR influenţează activitatea catepsinei H, iar CMT-67 + BioR – activitatea catepsinei L. În doze mari (10 mg/kg) este micşorată statistic veridic doar activitatea catepsinei G de către CMT-67, CMT-67 + BioR şi CMT-28 + BioR) şi a catepsinei H de către CMT-28 + BioR.en_US
dc.language.isoroen_US
dc.publisherCEP Medicinaen_US
dc.titleInfluenţa compuşilor coordinativi ai cuprului asupra activităţii proteazelor lizozomale hepatice în intoxicaţia cu propilenglicolro
dc.title.alternativeInfluence of the coordinative copper compounds on the activity of liver lisosomal proteases in propylene glycol poisoningen_US
dc.typeArticleen_US
Appears in Collections:Biochimie și genetică

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