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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/3986
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dc.contributor.authorAmbros, Ala
dc.contributor.authorLîsîi, Leonid
dc.contributor.authorCebotari, Inga
dc.contributor.authorRusu, Daniela
dc.contributor.authorLuţcan, Cristina
dc.date.accessioned2019-06-25T11:34:58Z-
dc.date.available2019-06-25T11:34:58Z-
dc.date.issued2010
dc.identifier.citationAMBROS, Ala, LÎSÎI, Leonid et al. Monoxidul de carbon – messager gazos în circulaţia cerebrovasculară. In: Anale Științifice ale USMF “Nicolae Testemiţanu”. Ed. a 11-a. Chișinău: CEP Medicina, 2010, vol. 1: Probleme medico-biologice si farmaceutice, pp. 240-248.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/3986-
dc.descriptionCatedra de Biochimie şi Biochimie Clinică USMF „N.Testemiţanu”en_US
dc.description.abstractThe primary objectives of this article are to review the potential role of carbon monoxide (CO) as an endogenous mediator in cerebrovascular circulation. It is produced from heme by a constitutively expressed enzyme (heme oxygenase (HO)-2) expressed highly in the brain and by an inducible enzyme (HO-1). CO production is regulated by controlling substrate availability, HO-2 catalytic activity, and HO-1 expression. CO dilates arterioles by binding to heme that is linked to large conductance Ca2+ activated K+ channels (BKCa channels), which elevates channel Ca2+ sensitivity, increases coupling of Ca2+ sparks to BKCa channel openings and, thereby, hyperpolarizes the vascular smooth muscle. In addition to dilating blood vessels, CO can either inhibit or accentuate vascular cell proliferation and apoptosis, depending on conditions. Rolul monoxidului de carbon (CO) ca mediator endogen în circulaţia cerebrovasculară reprezintă conţinutul acestui articol. Este produs de hem la acţiunea unei enzime constitutive (hemoxigenaza (HO)-2) expresată intens în creier şi a unei enzime inductibile (hemoxigenaza (HO)-1). Sinteza CO este reglată prin controlul cantităţii de substrat disponibil, activitatea catalitică a HO-2 şi expresia HO-1. CO induce dilatarea arteriolelor prin cuplarea cu proteina hem şi ataşarea acestui complex la canalele BKCa, mărind astfel afinitatea canalelor faţă de ionii de Ca2+. Ulterior are loc cuplarea ionilor la canal şi activarea lor, ceea ce duce la hiperpolarizarea membranei prin transportul ionilor de K+ in exteriorul celulei. În afară de acţiunea vasodilatatoare, CO poate inhiba sau induce atît proliferarea, cît şi apoptoza celulelor vasculare, în dependenţă de condiţii.en_US
dc.language.isoroen_US
dc.publisherCEP Medicinaen_US
dc.titleMonoxidul de carbon – messager gazos în circulaţia cerebrovascularăen_US
dc.title.alternativeCarbon monoxide as a gaseous messenger in the cerebrovacular circulationen_US
dc.typeArticleen_US
Appears in Collections:Biochimie și genetică

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