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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/3992
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dc.contributor.authorCheptea, Eduard
dc.contributor.authorGonciar, Veaceslav
dc.date.accessioned2019-06-25T11:46:08Z-
dc.date.available2019-06-25T11:46:08Z-
dc.date.issued2010
dc.identifier.citationCHEPTEA, Eduard, GONCIAR, Veaceslav. Unele aspecte metabolice ale interacţiunii derivaţilor izotioureici cu oxigenul hiperbaric. In: Anale Științifice ale USMF “Nicolae Testemiţanu”. Ed. a 11-a. Chișinău: CEP Medicina, 2010, vol. 1: Probleme medico-biologice si farmaceutice, pp. 379-388.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/3992-
dc.descriptionCatedra Farmacologie şi Farmacie clinică, Centrul Ştiinţific al Medicamentului USMF „Nicolae Testemiţanu”en_US
dc.description.abstractIn the experiments on rats the aspects of the isothioureic derivatives interaction with hyperbaric oxygen (HBO) on the lipid metabolism level was studied. HBO (6 ata 50 min) caused the increase of plasmatic concentration of total lipids, total phospholipids, total cholesterol, esterified cholesterol, fatty nonesterified acids, total lipoproteins, α+γ-lipoproteins, β-lipoproteins, cholesterol of lipoproteins. Izoturone (20 mg/kg) in normobaric conditions provoked the decrease of the content of total lipids, fatty nonesterified acids and the increase of total lipoproteins cholesterol and β-lipoproteins cholesterol. Diphetur (20 mg/kg) in normobaric conditions caused the increase of the level of total lipids and decrease of total lipoproteins, α+γ-lipoproteins, β-lipoproteins and their cholesterol. A complex metabolic interaction on the level of lipidic and lipoproteinic metabolism on the simultaneous prescription of izoturone, diphetur and HBO was revealed. In majority of cases the izoturone, the diphetur and the HBO reciprocally normalized the modification of parameters of lipidic metabolism, in others pharmacological agents act similarly manifasting a tendency of effects accumulation. În experimente pe şobolani au fost studiate aspectele metabolice ale interacţiunii derivaţilor izotioureici cu oxigenul hiperbaric (OHB) la nivelul metabolismului lipidic. OHB (6 ata, 50 min) a cauzat majorarea concentraţiei plasmatice de lipide totale, fosfolipide totale, colesterol total, colesterol esterificat, acizi graşi neesterificaţi, lipoproteine totale, α+γ-lipoproteine, β- lipoproteine, colesterol al lipoproteinelor. Izoturonul (20 mg/kg) în condiţii normobarice a provocat descreşterea concentraţiei de lipide totale, acizi graşi neesterificaţi şi a sporit de colesterol al lipoproteinelor totale şi colesterol al β-lipoproteinelor. În condiţii atmosferice obişnuite difeturul (20 mg/kg) a mărit nivelul de lipide totale şi a redus de lipoproteine totale, β-lipoproteine, α+γ-lipoproteine şi colesterol în ele. La administrarea concomitentă a derivaţilor izotioureici cu OHB s-a depistat o interacţiune complexă la nivelul metabolismului lipidic. În majoritatea cazurilor izoturonul, difeturul şi OHB normalizează reciproc modificările parametrilor metabolismului lipidic, în altele – agenţii farmacologici acţionează similar, manifestând tendinţă de acumulare a efectelor.en_US
dc.language.isoroen_US
dc.publisherCEP Medicinaen_US
dc.titleUnele aspecte metabolice ale interacţiunii derivaţilor izotioureici cu oxigenul hiperbaricen_US
dc.title.alternativeSome metabolic aspects of the isothioureic derivatives interaction with hyperbaric oxygenen_US
dc.typeArticleen_US
Appears in Collections:Farmacologie și farmacologie clinică

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