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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/4013
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dc.contributor.authorSolonari, Rodica
dc.date.accessioned2019-06-25T11:53:52Z-
dc.date.available2019-06-25T11:53:52Z-
dc.date.issued2010
dc.identifier.citationSOLONARI, Rodica. Aspecte biofarmaceutice şi farmacocinetice de administrare a captoprilului la copii. In: Anale Științifice ale USMF “Nicolae Testemiţanu”. Ed. a 11-a. Chișinău: CEP Medicina, 2010, Vol. 1: Probleme medico-biologice şi farmaceutice, pp. 460-465.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/4013-
dc.descriptionCatedra Tehnologia medicamentelor USMF „Nicolae Testemiţanu”en_US
dc.description.abstractThe main pharmacokinetic parameters and molecular structure data of captopril were highlighted. On the basis of this parameters of molecular structural data correspondency to Lipinski's rule or "rule of five” were established. The percentage of ionized molecules of captopril was calculated in different segments of the gastrointestinal tract. According to these data the oral administration of captopril do not create problems of absorption. Au fost evidenţiaţi principalii parametri farmacocinetici şi datele structural-moleculare ale captoprilului. În baza acestor parametri s-a stabilit corespinderea datelor structural moleculare conform regulii lui LIPINSKI sau „regula celor 5”. A fost calculat procentul de molecule neionizate ale captoprilului în diferite segmente ale tractului gastrointestinal. Conform acestor date administrarea pe cale orală a captoprilului, nu ar crea probleme de absorbţie.en_US
dc.language.isoroen_US
dc.publisherCEP Medicinaen_US
dc.titleAspecte biofarmaceutice şi farmacocinetice de administrare a captoprilului la copiien_US
dc.title.alternativeBiopharmaceutical and pharmacokinetic aspects of captopril administration in childrenen_US
dc.typeArticleen_US
Appears in Collections:Chimie generală și farmaceutică. Tehnologia medicamentelor (2)



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