USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7449
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSaenko, A.V.
dc.contributor.authorZaichko, N.V.
dc.contributor.authorStepanyuk, G.I.
dc.date.accessioned2020-02-12T12:44:08Z
dc.date.available2020-02-12T12:44:08Z
dc.date.issued2014
dc.identifier.citationSAENKO, A. V.; ZAICHKO, N. V.; STEPANYUK, G. I. Влияние натриевой соли 3-(2-оксо-3-фенил-2Н-[1,2,4]триазина[2,3-с] хиназолин-6-ил) пропановой кислоты и бемитила на биохимические процессы в организме крыс в условиях ежедневных тренировок в третбане. In: Curierul Medical. 2014, vol. 57, no 6, pp. 31-36. ISSN 1875-0666.en_US
dc.identifier.issn1875-0666
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/7449
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2016/09/Cm-6-2014-Electronic-version.pdf
dc.descriptionDepartment of Pharmacology, N. I. Pirogov National Medical University of Vinnitsa, Ukraineen_US
dc.description.abstractBackground: The limited arsenal of actoprotectors by almost one bemethyl has caused the necessity to search the substances with the above action, suitable for the creation of a new drug on their basis. Material and methods: For the investigation the substances of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c]quinazolin-6-yl) propane acid with the laboratory ciphers MT-279 has been taken. The studies have been performed on 56 nonlinear male rats in the conditions of the 15-daily physical loading which promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant». Results: It has been established that the course (15 days) intraperitoneal injections in rats with sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4] triazine[2,3-c]quinazolin-6-yl) propane acid (MT-279, 2.5 mg/kg), as well as bemethyl (33 mg/kg) promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant». Conclusions: The compound MT-279 has the largest actoprotective effect virtually mapped to bemethyl. A complex of effects inherent of MT-279 compound indicates the advisability of the in-depth study of its pharmacological properties to find out its safety and suitability for creating a new drug on its basis.en_US
dc.language.isoruen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofCurierul Medical
dc.subjectpropanoic aciden_US
dc.subjectactoprotective actionen_US
dc.subjectMT-279en_US
dc.subjectbemethylen_US
dc.subjectmetabolic processesen_US
dc.subject.meshPropionates--pharmacologyen_US
dc.subject.meshPropionates--therapeutic useen_US
dc.subject.meshMotor Activityen_US
dc.subject.meshPhysical Conditioning, Animalen_US
dc.subject.meshRatsen_US
dc.subject.meshSodium Chloride--therapeutic useen_US
dc.subject.meshBenzimidazoles--therapeutic useen_US
dc.subject.meshBenzimidazoles--pharmacologyen_US
dc.subject.meshRunningen_US
dc.titleВлияние натриевой соли 3-(2-оксо-3-фенил-2Н-[1,2,4]триазина[2,3-с] хиназолин-6-ил) пропановой кислоты и бемитила на биохимические процессы в организме крыс в условиях ежедневных тренировок в третбанеen_US
dc.title.alternativeEffect of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c] quinazolin-6-yl) propanoic acid and bemityl on biochemical processes in rats organism in the conditions of the daily training with running in treadmillen_US
dc.typeArticleen_US
Appears in Collections:Curierul Medical, 2014, Vol. 57, Nr. 6



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback