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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7841
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dc.contributor.authorNikolaev, V. A.
dc.contributor.authorSamura, B. A.
dc.date.accessioned2020-03-23T15:29:11Z
dc.date.available2020-03-23T15:29:11Z
dc.date.issued2013
dc.identifier.citationNIKOLAEV, V. A., SAMURA, B. A. Исследование антиэкссудативной активности производных эризимина и цимарина. In: Curierul Medical. 2013, vol. 56, no 6, pp. 32-35. ISSN 1875-0666.ru
dc.identifier.issn1875-0666
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/7841
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2016/09/75.pdf
dc.description.abstractComparative investigation of antiexudative activity-chemical structure dependence in a series of erysimine and cymarine derivatives was conducted on the model of carrageenan edema in white Wistar rats. The test substances were administered intragastrically at a dose of 5.0 mg/kg 30 minutes before introduction of the phlogogenic agent. Edema was caused by injection of 0.1 ml of 1% aqueous suspension of carrageenan. Antiexudative activity was determined by the degree of edema reduction in experimental animals as compared to control ones and expressed as a percentage. Diclofenac sodium was used as a comparative drug. The highest antiexudative activity among the erysimine derivatives was shown by 3’,4’-О-propylidene-erysimine that reduced the carrageenan edema by 39.4% (p < 0.05) and provided an anti-inflammatory effect comparable with the effect of diclofenac sodium. Replacing ethyl radical with propyl, phenyl, methyl, phenylpropenoic and 3-methoxy-4-hydroxyphenyl radicals decreased the antiexudative activity from 39.4 % to 13.5 %. Derivatives of cymarine have a less pronounced antiexudative activity: ethanoliminocymarine reduced the volume of edema in rats by 29.9% (p < 0.05). Replacing ethanol with pyridine-para-methylene and urea reduced the antiexudative activity from 29.9% to 9.0%. Erysimine and cymarine derivatives are a promising group of organic compounds for further synthesis and pharmacological screening to be used as a basis for development of medicines with antiexudative activity.en_US
dc.language.isoruen_US
dc.publisherMinisterul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”en_US
dc.subjectantiexudative activityen_US
dc.subjecterysimineen_US
dc.subjectcymarineen_US
dc.subject3’,4’-О-propylidene-erysimineen_US
dc.subjectethanoliminocymarineen_US
dc.subject.meshCymarine--pharmacologyen_US
dc.subject.meshErysiminum--pharmacologyen_US
dc.subject.meshInflammation--chemically induceden_US
dc.subject.meshInflammation--drug therapyen_US
dc.subject.meshAnti-Inflammatory Agents--pharmacologyen_US
dc.subject.meshExudates and Transudates--drug effectsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshRatsen_US
dc.titleИсследование антиэкссудативной активности производных эризимина и цимаринаru
dc.title.alternativeResearch of antiexudative activity of erysimine and cymarine derivativesen_US
dc.typeArticleen_US
Appears in Collections:Curierul Medical, 2013, Vol. 56, Nr. 6

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