Antibioticorezistenţa/sensibilitatea în infecţiile septico-purulente nosocomiale de profil ortopedo-traumatologic

Abstract

The study describes the antibiotic resistance of causative agents of purulent septic infections in patients of hospitals of ortopedic and traumatological profile. It includes 1269 patients from whom 2013 strains of microorganisms have been isolated. As a result of the analysis of antibiograms, a high resistance of strains to antibiotics have been detected (50.16%), including gram-negative microorganisms – 57.72% and gram-positive ones – 46.09%. A high level of antibiotic resistance has been identified in such microorganisms as Acinetobacter (85.72%), E. cloacae (71.43%), C. diversus (64.78%), K. pneumoniae (64.54%) and P. aeruginosa (62.78%). Depending on the antibiotic group, a higher resistance of these strains to penicillins (63.95%), cephalosporins (66.15%) and, especially, to the third generation of cephalosporins (69.35%) has been detected. Purulent septic pathology in hospitals of ortopedic and traumatological profile is of poly-etiologic nature and characterized by a high resistance of the pathogen agents to antibiotics. At the same time, the sensitivity/resistance of the causative agents is very diverse, the values of which, depending on the group of antibiotics, are from 29.0 to 97.0% – sensitive, and vice versa, from 26.0 up to 98.0% – resistant. A high resistance to antibiotics has been established in gram-negative microorganisms (57.72%), including Acinetobacter (85.72%), E. cloacae (free 71.43%), C. diversus (64.78%), K. pneumoniae (64.54%), P. aeruginosa (62.78%), in particular, to penicillins and cephalosporins, the antibiotics widely used in medical practice. The results of the study demonstrate the need for the development and implementation of the programme on surveillance and control of microbial antibiotic resistance suitable to a medical hospital.