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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/8593
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dc.contributor.authorLisii, D.
dc.contributor.authorTagadiuc, O.
dc.contributor.authorSardari, V.
dc.date.accessioned2020-04-22T10:54:33Z
dc.date.available2020-04-22T10:54:33Z
dc.date.issued2015
dc.identifier.citationLISII, D., TAGADIUC, O., SARDARI, V. Metabolismul glucozei în cancer şi rolul dietei cetogene. In: Curierul Medical. 2015, vol. 58, no 2, pp. 56-64. ISSN 1875-0666.en_US
dc.identifier.issn1875-0666
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2016/09/Cm-2-PDF.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/8593
dc.descriptionDepartment of Biochemistry and Clinical Biochemistry, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldovaen_US
dc.description.abstractBackground: One of the fundamental metabolic characteristics of cancer tissues is high consumption of glucose by cancer cells. The purpose of this article is determination of the features in the energy metabolism of cancer cells, elucidation of energy metabolism due to the major nutritive substrates, such as glucose and glutamine, evaluation of lactate dehydrogenase (LDH) as a potential marker of malignancies, estimation of the ketogenic diet in the treatment of cancer. The cells with higher degree of proliferation have a lower level of reduced Nicotinamide Adenine Dinucleotide (NADH), confirming the hypothesis: anabolic processes are predominant in cancer. The preferred way of glucose utilization in cancer tissues is the conversion of pyruvate to lactate, a phenomenon known as aerobic glycolysis or Warburg effect. Tumors with a high level of aerobic glycolysis are the most aggressive. The fact that LDHA (which catalyzes the reversible reaction of pyruvate to lactate) reflects the aggressiveness of the tumor and demonstrates the importance of aerobic glycolytic metabolism (the Warburg effect) in the survival of tumor cells. Conclusions: Multiple studies have mentioned the possibility of using glutamine instead of glucose by the cancer cells. Use of glutamine is another way of generating energy contributing to tumor cell survival. It was established that on substitution of glucose with ketone bodies (ketogenic diet), cancer cells can not adapt and die. Modulation of energy metabolism represents a new stage in the treatment of cancer. The substitution of glucose with lipids in the feed ration (ketogenic diet) is a non-toxic method of cancer management, both in prevention and treatment .en_US
dc.language.isoroen_US
dc.publisherThe Scientific Medical Association of Moldovaen_US
dc.relation.ispartofCurierul Medical
dc.subjectcanceren_US
dc.subjectaerobic glycolysisen_US
dc.subjectlactate dehydrogenaseen_US
dc.subjectthe Warburg effecten_US
dc.subjectketogenic dieten_US
dc.subject.meshNeoplasms--metabolismen_US
dc.subject.meshNeoplasms--diet therapyen_US
dc.subject.meshGlucose--metabolismen_US
dc.subject.meshDiet, Ketogenicen_US
dc.titleMetabolismul glucozei în cancer şi rolul dietei cetogeneen_US
dc.title.alternativeGlucose metabolism in cancer and the role of ketogenic dieten_US
dc.typeArticleen_US
Appears in Collections:Curierul Medical, 2015, Vol. 58, Nr. 2

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