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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/9360
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dc.contributor.authorSprincean, Mariana
dc.contributor.authorHadjiu, Svetlana
dc.contributor.authorBejan, Nadejda
dc.contributor.authorFoca, Silvia
dc.contributor.authorLupușor, Nadejda
dc.contributor.authorCălcîi, Cornelia
dc.contributor.authorTihai, Olga
dc.contributor.authorRevenco, Ninel
dc.date.accessioned2020-05-11T10:31:21Z
dc.date.available2020-05-11T10:31:21Z
dc.date.issued2018
dc.identifier.citationSPRINCEAN, Mariana, HADJIU, Svetlana, BEJAN, Nadejda, FOCA, Silvia-Gabriela, LUPUŞOR, Nadejda, CĂLCÎI, Cornelia, TIHAI, Olga, REVENCO, Ninel. Particularitățile accidentului vascular cerebral la copii cu displazii ereditare ale ţesutului conjunctiv. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale. 2018, nr. 1(58), pp. 39-44. ISSN 1857-0011.en_US
dc.identifier.issn1857-0011
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/9360
dc.descriptionIMSP Institutul Mamei şi Copilului USMF „Nicolae Testemiţanu”en_US
dc.description.abstractSubstratul genetic al accidentului vascular cerebral (AVC) ischemic şi hemoragic este adesea poligenic sau multifactorial. AVC la copii poate să rezulte deseori dintr-o boală monogenică. În afară de arteriopatii şi tulburări metabolice, mai multe displazii ale ţesutului conjunctiv pot cauza AVC la copii. Displaziile ereditare ale ţesutului conjunctiv (DEŢC) reprezintă un grup de patologii ereditare, monogenice, determinate de mutaţii în genele responsabile de sinteza şi metabolismul colagenului. În timp ce unele dintre aceste boli au fost recunoscute de zeci de ani drept cauze ale AVC, cum ar fi sindromul Ehlers-Danlos, tipul vascular, altele au ajuns recent în atenţie ca fi ind implicate în patogeneza AVC, cum ar fi cele legate de colagenul de tip IV. În această lucrare sunt abordate unele tulburări ereditare ale ţesutului conjunctiv şi relaţia lor cu AVC la copii, subliniind principalele caracteristici clinice care pot duce la diagnosticarea lor, dar şi prezentarea unui caz clinic.en_US
dc.description.abstractThe genetic substrate of the ischemic and hemorrhagic stroke is often polygenic or multifactorial. Stroke in children can often result from a monogenic disease. Apart from arteriopathies and metabolic disorders, hereditary dysplasia of connective tissue (HDCT) also can cause stroke in children. HDCT represents a group of hereditary, monogenic pathologies determined by mutations in the genes responsible for collagen synthesis and metabolism. While some of these diseases have been recognized for decades as causes of stroke, such as Ehlers-Danlos syndrome (the vascular type), others have recently come to scientists’ attention as being involved in the pathogenesis of stroke, such as the diseases caused by mutations in collagen type IV. We approach some hereditary connective tissue disorders and their relationship to stroke in children, highlighting the main clinical features that can lead to their diagnosis, as well as presenting a clinical case.
dc.description.abstractГенетический субстрат ишемического и геморрагического инсульта часто является полигенным или мультифакториальным. Инсульт у детей часто может быть результатом моногенного заболевания. Помимо артериопатий и нарушений обмена веществ, наследственные дисплазии соединительной ткани (HДCT) также могут вызывать инсульт у детей. HДCT представляют собой группу наследственных, моногенных патологий, определяемых мутациями в генах, ответственных за синтез и метаболизм коллагена. Хотя некоторые из этих заболеваний были признаны десятилетиями как причины инсульта, такие как синдром Элерса-Данлоса (сосудистый тип), другие недавно привлекли внимание ученых к участию в патогенезе инсульта, таких как болезни, вызванные мутациями в коллагене типа IV. В данной работе рассматриваются некоторые наследственные нарушения соединительной ткани и их связь с инсультом у детей, а также представлен клинический случай.
dc.language.isoroen_US
dc.publisherBuletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicaleen_US
dc.subjectstrokeen_US
dc.subjecthereditary dysplasia of connective tissueen_US
dc.subjectneurological signsen_US
dc.titleParticularitățile accidentului vascular cerebral la copii cu displazii ereditare ale ţesutului conjunctiven_US
dc.title.alternativePeculiarities of stroke in children with hereditary dysplasia of connective tissueen_US
dc.title.alternativeОсобенности инсульта у детей с наследственными дисплазиями соединительной тканиen_US
dc.typeArticleen_US
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