Issue dedicated to the 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020) http://repository.usmf.md:80/handle/20.500.12710/11690 2026-04-08T21:08:42Z 2026-04-08T21:08:42Z http://repository.usmf.md:80/handle/20.500.12710/16912 2021-09-22T14:48:50Z 2020-01-01T00:00:00Z

Title: The Moldovan Medical Journal. October 2020, Vol. 63, No 4 Abstract: The Moldovan Medical Journal is an international scientific double-blind peer-reviewed periodical edition, 4 per year, of the Scientific Medical Association of the Republic of Moldova designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine, and public health. From its debut, the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors of the journal, all those who are enthusiastic about searching for new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Description: 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020). Founder: The Scientific Medical Association of the Republic of Moldova

2020-01-01T00:00:00Z Cușnir, Valeriu Dumbraveanu, Lilia Groppa, Liliana Cușnir, Vitalie Bobescu, Nicolae Cușnir, Valeriu Jr. http://repository.usmf.md:80/handle/20.500.12710/11736 2025-02-17T07:44:46Z 2020-01-01T00:00:00Z

Title: Inflammatory glaucoma. Elements of etiology and pathology Authors: Cușnir, Valeriu; Dumbraveanu, Lilia; Groppa, Liliana; Cușnir, Vitalie; Bobescu, Nicolae; Cușnir, Valeriu Jr. Abstract: Background: Inflammatory glaucoma, also known as uveitic glaucoma is a multifactorial process of inflammation that causes the rising of intraocular pressure (IOP) accompanied by morphological and physiological modifying similar to open angle glaucoma. The mechanisms by which ocular inflammation causes an increase of the IOP are not integrally comprehended, and many of the relevant pathways and features are still covered with a veil of mystery. The eyes of uveitic patients are defined by complex interactions between the angles (open or closed), trabecular outflow, fluctuations in the aqueous production and the response to steroids. Regarding the elevation of IOP in these individuals, it is mostly attributed to the increased outflow resistance, which distorts the equilibrium between aqueous production and outflow. Conclusions: Inflammatory glaucoma is a multifactorial pathology that needs a careful diagnosis and therapeutical approach in order to obtain a good management of inflammatory process and intraocular pressure. There are a lot of pathological pathways that influence the evolution of inflammatory glaucoma and make treatment more difficult. Last years, glaucoma treatment has significantly improved, but to better understand pathogenesis of uveitic glaucoma more scientific studies are necessary. Key words: inflammatory glaucoma, uveitic glaucoma, secondary glaucoma. Description: Department of Ophthalmology and Optometry, Department of Internal Medicine, Rheumatology and Nephrology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)

2020-01-01T00:00:00Z Groppa, Stanislav Zota, Eremei Bodiu, Adrian Gasnas, Alexandru Manole, Elena Ciobanu, Natalia Leahu, Pavel Efremova, Daniela Crivorucica, Igor Glavan, Danu Balanuta, Tatiana http://repository.usmf.md:80/handle/20.500.12710/11735 2021-09-23T07:06:15Z 2020-01-01T00:00:00Z

Title: Diagnosis and management of ischemic stroke: time is critical Authors: Groppa, Stanislav; Zota, Eremei; Bodiu, Adrian; Gasnas, Alexandru; Manole, Elena; Ciobanu, Natalia; Leahu, Pavel; Efremova, Daniela; Crivorucica, Igor; Glavan, Danu; Balanuta, Tatiana Abstract: Background: It is predicted that stroke’s incidence and impact will increase considerably over time. Proper management of stroke depends on a reliable and urgent diagnosis that includes patient / relative - emergency team - hospital chain, so the diagnosis begins with the recognition of the first signs of stroke. In order to act promptly in the acute period and subsequently assess the risk factors, the neurological service needs to be equipped with highperformance neuroimaging and clinical laboratory. The specific treatment of acute ischemic stroke is nowadays the reperfusion procedure, performed by thrombolytic therapy and, since 2015, by the endovascular treatment. Stroke is also a leading cause of severe long-term disability. The rehabilitation of post-stroke patients requires an interdisciplinary approach, in order to prevent recurrences, combat complications and reintegrate the patient into society. Conclusions: Stroke remains one of the leading determinants of death and severe disability worldwide and the Republic of Moldova is not an exception. Considering the narrow window for recognition and administration of outcome-modifying treatment, the management of stroke focuses mainly on rapid reperfusion via intravenous thrombolysis and endovascular thrombectomy. The availability of this specialized treatment in the Stroke Unit could improve the patient’s outcome and decrease the disability’s level and economical burden. There is clear evidence that preventing a stroke is much more effective than treating it, so we should seize the opportunity and act involving not only the medical staff, but also the government, health decision makers, specialists in public health and international agencies. Description: Department of Neurology No 2, Department of Neurology No 1, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, Department of Neurology, Epileptology and Internal Diseases, Department of Neurosurgery, Laboratory of Cerebrovascular Diseases and Epilepsy, National Center of Epileptology Institute of Emergency Medicine, Chisinau, the Republic of Moldova, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)

2020-01-01T00:00:00Z Podgornii, Ana Valica, Vladimir Pogrebnoi, Serghei Lupascu, Lucian Uncu, Andrei Macaev, Fliur http://repository.usmf.md:80/handle/20.500.12710/11734 2021-09-23T07:08:46Z 2020-01-01T00:00:00Z

Title: Antimycotic activity of phenoxythiazolchloralum Authors: Podgornii, Ana; Valica, Vladimir; Pogrebnoi, Serghei; Lupascu, Lucian; Uncu, Andrei; Macaev, Fliur Abstract: Background: The therapeutic options in invasive candidiasis and aspergillosis are limited and don’t provide expected results. Introducing a new drug in the therapeutic practice can improve the quality of life of immunocompromised patients. The aim of this research is to study the antimycotic activity of new substance phenoxithiazolchloralum (MF-0010) on Aspergillus spp., Candida albicans, and Saccharomyces cerevisiae. Material and methods: Phenoxythiazolchoralum has been kindly offered by the Institute of Chemistry. The standards were offered by Nicolae Testemitanu State University of Medicine and Pharmacy. Antifungal activity of the phenoxythiazolchloralum against Aspergillus spp. was evaluated by microdilution method. The successive double dilution method was used for determination of in vitro susceptibility against Candida albicans, and Saccharomyces cerevisiae. Results: For the first time, it was studied in vitro susceptibility of MF-0010 against Aspergillus spp., Candida albicans, Saccharomyces cerevisiae. With at least 0.05 μM/ml difference of MF-0010 MIC value from standards, it can be considered quite more potent than ketoconazole and bifonazole against Aspergillus fumigatus, Aspergillus versicolor, Aspergillus ochramensis. The MIC/MCF ratios of MF-0010 are lower than nistatine ones with 0.08 μMol for both pathogens: Candida albicans, and Saccharomyces cerevisiae. Conclusions: All analyzed pathogens were susceptible to MF-0010. According to experimental data on Aspergillus spp., the antimycotic activity of MF-0010 is quite better than the standards one. The MIC/MCF ratios showed in vitro significant susceptibility of MF-0010 against Candida albicans. Description: Department of Pharmaceutical and Toxicological Chemistry, Drug Scientific Center, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, Laboratory of Organic Synthesis and Biopharmaceuticals, Institute of Chemistry, Chisinau, the Republic of Moldova, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)

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