http://repository.usmf.md:80/handle/20.500.12710/16081 2026-10-25T13:36:51Z 2026-10-25T13:36:51Z http://repository.usmf.md:80/handle/20.500.12710/16256 2021-09-27T06:42:11Z 2017-01-01T00:00:00Z

Title: The Moldovan Medical Journal. April 2017, Vol. 60, No 2 Abstract: The journal was founded in 1958 on the initiative of Nicolae Testemitsanu, an outstanding expert in orthopedics, social medicine, and public health. Now the publisher of the journal is the Scientific Medical Association of Moldova and the journal has become the scientific peer-reviewed periodical Edition designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine, and public health. From its debut the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The aim of the Moldovan Medical Journal is to provide the international community with the results of scientific researches performed in the medical institutions of Moldova and inform Moldovan medical society about the advanced achievements of medicine abroad. The Editorial Board warmly welcomes both the readers of and the authors of the journal, all those who are enthusiastic about searching for new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Description: Fondatori: Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie “Nicolae Testemiţanu”

2017-01-01T00:00:00Z Vataman, Vladimir http://repository.usmf.md:80/handle/20.500.12710/14061 2021-09-27T06:42:30Z 2017-01-01T00:00:00Z

Title: Monograph “Pituitary adenomas. Morphopathology and molecular profile”, the author: Eugen Melnic Authors: Vataman, Vladimir Description: Department of Morphopathology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova

2017-01-01T00:00:00Z Grib, Liviu Cenusa, Octavian Varvariuc, Viorica Abraș, Marcel Grib, Andrei Grajdieru, Romeo http://repository.usmf.md:80/handle/20.500.12710/2720 2024-01-03T11:41:47Z 2017-01-01T00:00:00Z

Title: Radiofrequency ablation – new insights into the modern treatment of atrial flutter and fibrillation Authors: Grib, Liviu; Cenusa, Octavian; Varvariuc, Viorica; Abraș, Marcel; Grib, Andrei; Grajdieru, Romeo Abstract: Background: Atrial fibrillation (AF) is associated with a 5-fold increase in the risk of stroke and a 3-fold increase in the incidence of heart failure. The increase in AF prevalence can be attributed both to better detection of silent AF, alongside increasing age and conditions predisposing to AF. Nonpharmacological measures aimed at «healing» AF were initially tested in open surgery. Searching for an approach with a greater chance of success led to the development of radiofrequency ablation (RFA). Only recently RFA technique began to be used extensively in people with AF, not being tested in large randomized studies, with establishment of remote results. Conclusions: Catheter ablation is used successfully in patients suffering from symptomatic paroxysmal atrial fibrillation, as an alternative to drug therapy. Performed correctly by a trained and experienced electrophysiolologist, RFA allows us to get remarkable results, being possible suspension of treatment with antiarrhythmic drugs and to avoid its so well known side’s effects. RFA with catheter is superior to antiarrhythmic drug therapy in preventing recurrence in both persistent AF and in the paroxysmal AF. The success rate of RFA in experienced centers for paroxysmal AF exceeds 70% a year. RFA reintervention is necessary in the approximately 9-20% of patients with more modest results. The frequency of major complications related to RFA is less than 5%. The restored sinus rhythm with RFA in patients with heart failure may be associated with significant improvement in left ventricular ejection fraction. Description: Department of Internal Medicine, Medical clinic No 3, Discipline of Cardiology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova

2017-01-01T00:00:00Z Visternicean, Elena http://repository.usmf.md:80/handle/20.500.12710/2719 2021-09-27T06:44:04Z 2017-01-01T00:00:00Z

Title: The role of homocysteine in endothelial dysfunction Authors: Visternicean, Elena Abstract: Background: Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine, an essential amino acid. Hyperhomocysteinemia defines the state in which concentrations of homocysteine exceeds normal level. Homocysteine is located at a metabolic branch point and can either be irreversibly degraded to cysteine via the transsulfuration pathway, or conserved by remethylation back to methionine. Folic acid, vitamin B12, and vitamin B6 deficiencies and reduced enzyme activities inhibit the breakdown of homocysteine, thus increasing the concentration of intracellular homocysteine. Being cytotoxic, homocysteine is increasingly exported from the cell to become detectable in plasma. In recent years the amino acid homocysteine has achieved the status of an important factor in vascular disease, diseases of aging, and other fundamental processes in biology and medicine. Hyperhomocysteinemia may alter vascular morphology, stimulate inflammation, activate the endothelium and the blood clotting cascade, and inhibit fibrinolysis. As a result, hyperhomocysteinemia is associated with loss of endothelial antithrombotic function and induction of a procoagulant environment. The role of homocysteine in endothelial dysfunction is thought to be mediated by mechanisms including oxidative stress. Vascular injury could be caused by an imbalance between nitric oxide production from dysfunctional endothelial cells and homocysteine concentrations. Conclusions: Hyperhomocysteinemia is associated with alterations in vascular morphology, loss of endothelial antithrombotic function, and induction of a procoagulant environment. Description: Department of Obstetrics and Gynecology No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova

2017-01-01T00:00:00Z