DSpace Community: Moldovan Journal of Health Sciences

Invasive potential of cutaneous malignant melanoma

2026-04-27T12:47:02Z

Title: Invasive potential of cutaneous malignant melanoma Authors: Cenușa, Alexandrina; Foca, Ecaterina; Carpenco, Ecaterina; Brînza, Dumitru; David, Valeriu; Șaptefrați, Lilian; Fulga, Veaceslav Abstract: Introduction. Cutaneous malignant melanoma is the most aggressive skin cancer, with a high mortality rate despite advances in therapy. This study aimed to evaluate the relationship between lymphovascular and perineural invasion and key clinicopathological parameters in superficial spreading melanoma, in order to assess their potential prognostic significance. Materials and methods. A retrospective analysis was conducted on 47 cases of superficial spreading melanoma obtained from the Oncology Institute in Chisinau. All cases were histologically confirmed and reviewed for tumor thickness, Clark level, ulceration, mitotic activity, microsatellitosis, pigmentation, and lymph node involvement. Lymphovascular and perineural invasion were assessed using hematoxylin–eosin staining and, where available, immunohistochemistry. Correlations between invasion patterns and clinicopathologic features were analyzed using Pearson correlation coefficients, with statistical significance set at p < 0.05. Results. Lymphovascular invasion was positive and significantly correlated with tumor thickness (r = 0.54, p< 0.001), Clark level (r = 0.46, p < 0.001), microsatellitosis (r = 0.50, p < 0.001), tumor stage (r = 0.33, p = 0.01), and lymph node involvement (r = 0.29, p = 0.02). A negative correlation was observed with pigmentation (r = –0.26, p = 0.04). Perineural invasion was less frequent, but correlated positively with lymphovascular invasion (r = 0.28, p = 0.03) and showed a trend toward association with amelanotic tumors (r = –0.24, p = 0.05). No significant relationships were found with ulceration or mitotic activity. Conclusions. Lymphovascular invasion represents a significant indicator of aggressive biological behavior in superficial spreading melanoma, closely associated with established prognostic factors. Perineural invasion occurs less frequently, but may further reflect invasive potential, particularly in amelanotic variants. Routine histopathologic assessment of both invasion patterns is recommended to improve prognostic evaluation.

The role of odontogenic infection in the onset and evolution of focal disease

2026-04-06T06:43:51Z

Title: The role of odontogenic infection in the onset and evolution of focal disease Authors: Ciobanu, Sergiu; Marcu, Diana; Roman, Ion; Musteață, Olesea

Refractive lens exchange in a patient with high myopia and myopic astigmatism: a clinical case report

2025-12-16T08:40:16Z

Title: Refractive lens exchange in a patient with high myopia and myopic astigmatism: a clinical case report Authors: Porada, Serghei; Tanurcova, Iulia; Paduca, Ala Abstract: Introduction. Refractive lens exchange is increasingly utilized for visual rehabilitation in patients with high myopia unsuitable for corneal refractive procedures. While effective, refractive lens exchange with intraocular lens implantation significantly improves visual acuity in young patients with high myopia and astigmatism, while maintaining a low risk of postoperative retinal complications, provided that thorough preoperative vitreoretinal assessment is conducted. However, it carries potential risks, notably retinal complications. Case presentation. We present a case involving a 45-year-old female with high axial myopia and myopic astigmatism who underwent bilateral refractive lens exchange with the implantation of monofocal intraocular lenses. Comprehensive preoperative assessments included optical biometry, tonometry, fundus examination, and visual acuity measurements. Postoperative recovery was uneventful in the right eye. However, the patient developed a retinal detachment in the left eye approximately one year post-surgery. This complication was successfully managed with pars plana vitrectomy, endolaser photocoagulation, and silicone oil tamponade, resulting in an improvement of visual acuity to 0.3. Conclusions. Refractive lens exchange can be an effective intervention for patients with high axial myopia but carries a risk of retinal detachment. Thorough preoperative evaluation, meticulous surgical technique, and patient counseling are essential. Prompt detection and management of complications like retinal detachment are crucial for preserving visual outcomes.

Digital planning in orthodontics. Applicability of the Kau, Pan, Gallerano index in contemporary orthodontics

2025-12-16T08:33:36Z

Title: Digital planning in orthodontics. Applicability of the Kau, Pan, Gallerano index in contemporary orthodontics Authors: Trifan, Valentina; Bolgari, Ana; Baiceva, Iana; Trifan, Daniela; Zumbreanu, Irina Abstract: Introduction. Digital planning in modern orthodontics is crucial in contemporary era, as it allows dentists to expand the limits of patients’ diagnosis and clinical treatment. Using tools such as 3D scanners, cone beam computed tomography with various software gives clinicians the opportunity to achieve more precise diagnoses and accurate predictions of treatments. In this way, digital imaging offers a precise localization of impacted canines which allows for the integration and applications of the Kau, Pan, Gallerano index. Material and methods. To assess the applicability of the Kau, Pan, Gallerano index and digital planning in orthodontics, this review evaluates key studies that explore various aspects of the topic. Scientific databases such as Cochrane Library, Medline, Scopus, Medicus, NCBI, PubMed, and Google Scholar were used to find the necessary articles. Research methods like analysis, synthesis, systematization and description were applied. Results. After analyzing the available data, this review presents the benefits and opportunities of digital orthodontics. The findings demonstrate that the Kau, Pan, Gallerano index offers high diagnostic accuracy by effectively categorizing various types of impactions. Moreover, the analysis reveals a strong correlation between the Kau, Pan, Gallerano index scores and successful treatment outcomes, showing that the index with digital technologies improves diagnostic accuracy and treatment planning. Conclusions. The reviewed literature collectively indicates that this index is a valuable tool in contemporary digital orthodontics. Its interdisciplinary connection with digital planning which provides strong predictive value, and its comprehensive assessment approach make it an important component in modern orthodontic practice. Future research should continue to explore the advantages and disadvantages of modern technologies used in orthodontic diagnosis and treatment planning, thus validating their efficiency and their applicability across diverse complex orthodontic cases.